Disease states, profiling enzyme activities

Figure 11 Enzymatic activity profile of mannose-terminal glucocerebrosidase in plasma of a boy with Gaucher disease. Enzyme was infused over 4 hours at a constant rate of 12.25 U/kg. A steady-state value of 10.6 mU/mL was achieved during the first hour. When the infusion was terminated at 240 minutes, enzyme was cleared from the plasma by a first-oider process with an elimination half-life of 6.3 minutes. The dashed line represents the activity profile calculated from the observed kinetic constants.

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