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Discovery program, drug candidate

Studies using free energy calculations for the design and analysis of potential drug candidates are reviewed in section five. The chapters in this section cover drug discovery programs targeting fructose 1,6-bisphosphatase (diabetes), COX-2 (inflammation), SRC SH2 domain (osteoporosis and cancer), HIV reverse transcriptase (AIDS), HIV-1 protease (AIDS), thymidylate synthase (cancer), dihydrofolate reductase (cancer) and adenosine deaminase (immunosuppression, myocardial ischemia). [Pg.403]

The first measure of a candidate compound s efficacy in a drug discovery program is its specific binding affinity to a desired biomolecular target. Therefore,... [Pg.130]

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Candidates

Candide

Discovery program

Drug, drugs program

Drugs discovery programs