Disaccharides database

Als-Nielsen B, Gluud CLL, Gluud C. Nonabsorbable disaccharides for hepatic encephalopathy. Cochrane Database Syst Rev 2004. 

Preparation of the chapter was based on a literature search through SCOPUS and the Beilstein Database, which identified 53 papers of value and which are discussed in this chapter. It is remarkable that so few papers appeared on fused thietanes and thietes during this period, and many of them are a continuation of previously published studies. To the best of our knowledge, only taxoids with fused thietane rings as well as mono- and disaccharides bearing fused thietane moieties constitute new classes of fused-ring thietanes and thietes. 

In order to address the problem of performing substructure searches for chiral moieties, a method of designating both absolute and relative configuration in molecular structures was developed. Then a small chemical structure database containing 25 mono and disaccharides was created in order to test the concept. Results from tests show this method to be viable and expandable to other types of compounds. 

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