Directed sorting approach synthesis

Directed Sorting Approach for the Synthesis of Large Combinatorial Libraries of Discrete Compounds... 

A system based on grafted polymer synthetic objects (lanterns) is available from Mimotopes Pyt. Ltd.12 The system is composed of the synthetic objects (lanterns), RF-Tags (Transtems), software to track the synthesis (TranSort), and a cleavage system. Additional systems that are not commercially available have been reported. Workers at Aventis have developed a highly automated system based on the Mimotope lanterns.13 Recently workers at Millenium Pharmaceuticals reported the St AC system (Stratified Adressable System), a three-dimensional spatial array that allows discrete compounds to be synthesized using the same efficiency as the directed sorting approach.14... 

Combinatorial syntheses can be performed in two ways (i) split-and-pool (also referred to as the split-and-mix or the split-and-recombine method)and its variant directed sorting" and (ii) parallel synthesis. A hybrid approach is the split-and-split technique. " ... 

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