Directed assembly system

Enei etics of the Basic Directed Assembly System... 

Knowledge about protein folding and conformation in biological systems can be used to mimic the design of a desired nanostructure conformation from a particular MBB and to predict the ultimate conformation of the nanostructure [152]. Such biomimetic nano-assembly is generally performed step by step. This wiU allow observation of the effect of each new MBB on the nanostructure. As a result, it is possible to control accurate formation of the desired nanostmcture. Biomimetic controlled and directed assembly can be utilized to investigate molecular interactions, molecular modeling, and study of relationships between the composition of MBBs and the final conformation of the nanostmctures. Immobilization of molecules on a surface could facilitate such studies [153]. 

The objectives of this review are to describe the types of structures that can be formed by self-assembly in these systems, to discuss the current experimental and theoretical issues of self-assembly, to assess the current role of theory in the predicting stability of self-assembled systems, and to highlight important future directions for self-assembled structures. 

There are now many self-assembled supramolecular systems in which metal ions have played an important, if not essential, role in the assembly process. In this chapter, the use of metal-directed synthesis to achieve assembled systems is discussed. 

It has been demonstrated that DPN can be used to create nanostructures on a surface which can then be used for directed assembly of nanoparticles [90]. In this application also the basic patterning by DPN was done with MHA as ink on an Au substrate. Subsequently, alkylamine-modified DNA was coupled to the MHA nanopatterns so created. By creating an ordered pattern of two distinct oligonucleotide sequences it was possible to create an ordered assembly of two different nanoparticles from a randomly dispersed system. 

Besides the technical advantages listed above, there are also some less direct benefits to adopting and promoting NeSSI in the laboratory. Unfortunately, much of the time spent conducting research involves assembling systems and... 

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