Dipropylene glycol toxicity

Rats showed no adverse effects from 5.0% dipropylene glycol in their drinking water for 77 days, but at a dose of 10.0% in the drinking water, kidney and Hver injury and some deaths occurred (35). A sufficient number of studies have not been carried out on tripropylene glycol to permit conclusions to be drawn regarding its chronic oral toxicity. 

Landry TD, Yano BL Dipropylene glycol monomethyl ether A 13-week inhalation toxicity study in rats and rabbits. Fundam Appl Toxicol 4-.6U-6n, 1984... 

Breslin WJ, Cieszlak FS, Zablotny CL, et al Evaluation of the developmental toxicity of inhaled dipropylene glycol monomethyl ether (DPGME) in rabbits and rats. Occup Hyg 2 161-70, 1996... 

Dipropylene glycol Relatively low toxicity. Central nervous system depression, hepatic injury, and renal damage have occurred In animal studies after massive exposures. There are no reports of acidosis or lactate elevation. Molecular weight is 134. Supportive care. There is no role lor ethanol therapy. 

Precautions Mildly toxic by swallowing and skin contact. A mild allergen and a skin and eye irritant. Synonyms cas 34590-940-8 dipropylene glycol monomethyl ether Dipropylene Glycol Monosalicylate... 

Dipropylene Glycol n (2,2 -dihydroxydipropyl ether) (CH3CHOH—CH2)20. a high-boiling glycol ether with a low order of toxicity, widely used as a solvent and chemical intermediate. As a solvent it is used with cellulose acetate and nitrate, and is one of the few known solvents for polyethylene. Thus it is used in screening tests to identify polyethylene. As an intermediate, dipropylene glycol reacts with dibasic acids to form alkyd resins, polyester plasticizers, and urethane-foam intermediates. 

Benzoate based plasticizers, e.g., Benzoflex 2888 which is a blend of diethylene glycol dibenzoate, triethylene glycol dibenzoate, and dipropylene glycol dibenzoate, have been developed to account for the leaching problems. Benzoflex seems to be a good alternative to phthalates in flexible toys due to its ease of processing, final product performance, low toxicity and fast biodegradation. Toxicity tests showed a low acute toxicity and no evidence of reproductive toxicity (2). 

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