Dipipanone

Reference compounds. Dipipanone Rf 66, pethidine Rf 37, desipramine Rf 20, codeine Rf 06. 

Reference compounds. Meclozine Rf 79, caffeine Rf 58, dipipanone Rf 33, desipramine Rf 11. 

Only medical practitioners who hold a special licence issued by the Home Secretary may prescribe diamorphine, dipipanone or cocaine for addicts other practitioners must refer the addict to a treatment centre. This stipulation only applies to addicts and does not preclude the prescription of diamorphine or cocaine for the relief of pain due to organic disease or injury (see also page 531 Chapter 17.15.3). 

Dimethothiazine, 374 Dimethoxanate, 390 Dimethylpyrindene, 145 Dimethylthiambutene, 106 Dimetridazole, 240 Dinoprost, 27, 33, 34 Dinoprostone, 27, 30, 33, 35 Dioscorea, see Mexican yam Diosgenin, 156, 182 Dioxyline, 349 Diphenhydramine, 41 Diphenidol, 45 Diphenoxylate, 302 Diphenylhydantoin, 246 Di phepanol, 46 Dipipanone, 80 Dipiproverin, 94 Dipyridamole, 428 Displacement, bromine by nitro, 247... 

The most known narcotics are the opium alkaloids such as morphine, codeine, thebaine, papaverine, noscapine and their derivatives and modified compounds such as nalmorphine, apomorphine, apomopholcodine, dihydrocodeine, hydro-morphone and heroine, also known as diamorphine. Synthetic narcotics share the structural skeleton of morphine and include dextromethorphan, pentazocine, phenazocine meperidine (pethidine), phentanyl, anfentaitil, remifentalin, methadone, dextropropoxyphene, levoproxyphene, dipipanone, dextromoramide, meptazinol and tramadol. Thebaine derivatives are also modified narcotics and include oxycodone, oxymorphone, etorphine, buprenorphine, nalbuphine, naloxone or naltrexone. Narcotics can be semi-synthesized or totally synthesized from the morphine and thebaine model. The compounds serve various purposes in clinical practise. 

The previous edition of this book contained a detailed description of abuse of the antiemetic tablet preparation cyclizine by illicit drug users, nearly always crushed and injected along with methadone tablets or ampoules. Cyclizine is a constituent of Diconal along with the opioid dipipanone, and it seems that cyclizine has an opioid-enhancing effect which partly accounts for the particularly euphoriant property of Diconal. This could therefore be reproduced by combining cyclizine with the synthetic opioid methadone, and the intention to do this led to a wave of patients in the UK attempting to have their methadone prescribed in the ampoule or tablet form. 

In general, dimethylamino gives optimum activity, but 5- and 6-membered alicyclic basic units also yield strong analgesic compounds (e.g. phenadoxone, dipipanone, dextromoramide)... 

Variation of the basic group of methadone has led to the morpholino (11a, phenadoxone, Heptalgin) and piperidino (lib, dipipanone, Pipadone)... 

Reference Solution. Prepare a solution in chloroform containing 10 P-g/ml of each of codeine, cyclizine, diphenhydramine, dipipanone, methadone, and pethidine. 

Narcotic Analgesics Anilendine, codeine, dextromoramide, diamorphine, dihydrocodeme, dipipanone, ethylmorphme, hydrocodone, hydromorphone, levorphanol, methadone, morphine, oxycodone, oxymorphone, pentazocine, pethidme, phenazocme, pimmodme, thebacon, tnmeperidine, and related compounds... 

Acepromazine (- red), adiphenine (-> blue), benorylate, bephenium hydroxynaphthoate, bibenzonium, buclosamide (blue rim), bunamidine, chlorpromazine (-> violet), clefamide (— brown), codeine, colchicine, cyclazocine, cyclomethycaine (— brown), debrisoquine, diaveridine, dibenzepin, diethazine (— violet with excess reagent), diethylthiambutene (-> green-blue), dimethindene, dimethoxanate (— brown), dimoxyline, dipipanone (— blue), dothiepin, doxorubicin, doxycycline (-> yellow), ethopropazine violet), fenpiprane,... 

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