Diphenylpropane Derivatives

Table 8. Cancer Cell Lines Inhibited by Other 1,2-Diphenylpropane Derivates.

Fig. (1). Main skeletons of flavonoids studied. Note that flavones, flavonols, flavanones and chalconesare 1, 3-diphenylpropane derivates, whereas isoflavones and rotenoids are 1,2-diphenylpropane derivates.

Other 1,2-diphenylpropane derivates Trivial name Cell type Reference... 

The major types of bioactive constituents reported from Broussonetia papyrifera are the prenylated flavonoids, which include compounds of the diphenylpropane, chalcone, flavan, flavanone, flavone, flavonol, and aurone classes (Table 2), Fig. (7). An early study on B. papyrifera resulted in the isolation of two diphenylpropanes, broussonins A (29) and B (30), and a coumarin, marmesin (52), with antifungal activity [39]. Also, a diprenylated diphenylpropane derivative, kazinol F (31) [40], was reported as an antioxidant and tyrosinase inhibitory constituent [34]. 

Cram and his associates (15) used the following acyloin reaction for the cyclization of the starting material to [3.3]para-cyclophane skeleton, because the reaction of the diphenylpropane derivative (II) gave very little amount of the desired cyclized product, even if the high dilution technique was employed. 

The effect of the conformation of the three carbon (C3) linkage with two or more methyl groups, however, is considered to be recognized in the polymerization, from the analogy to the results of the excimer fluorescence of 1,3-diphenylpropane derivatives (34,... 

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