Diphenylphosphorodiamidic chloride

The phosphorodiamidic chloride thus obtained was then fluorinated. For example, diphenylphosphorodiamidic chloride was readily fluorinated by heating it with potassium fluoride in benzene, POCl(NHPh)2 + KF - POF(NHPh), + KCl. 

The preparation of diphenylphosphorodiamidic chloride was first mentioned by Michaelis,1 who heated 2 mol. of aniline hydrochloride with 1 mol. of phosphorus oxychloride for 48 hr. He did not give a yield and we found the method long and tedious. We showed, however, that this compound is much more simply prepared by allowing 4 mol. of aniline to react with phosphorus oxychloride in cold ethereal solution, in accordance with equation (a). 

M,M-diphenylphosphorodiamidic chloride in pyridine. After the removal of the isopropylidene groups, the compound (19 ... 

AW -Diphenylphosphorodiamidic chloride has been recommended as a convenient phosphorylating reagent for the preparation of nucleoside 3 -phosphates since it is stable, it gives very high yields, and the resulting esters... 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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