3.5- diphenyl- -iodide

DIPHENYLIODONIUM IODIDE (Iodonium Compounds, diphenyl—iodide)... 

SYNS BIS(BENZENE)CHROMIUM(l-l-)IODIDE CHROMIUTV I-H), BIS(BENZENE)-, iodide (SCI) (CHROMIUM(l+), BIS(eta )-BENZENE)-, IODIDE (9CI) CHROMIUM, BIS(BENZENE)IODO- CHROMIUM(III), DIPHENYL-, IODIDE DIBENZENECHROMIUM IODIDE DIPHENYLCHROMIUM(III) IODIDE... 

Lead diphenyl di-o-tolyl. —To a solution of 5 6 grams of o-bromo-toluene and 0 8 gram of magnesium in dry ether, 5 grams of lead diphenyl iodide are slowly added. After the reaction has subsided, the mixture is heated for half an hour on the water-bath, cooled, and 25 c.c, of toluene added, the whole then being decomposed with dilute hydrochloric acid. The toluene-ether layer is separated, the solvents removed, and the residue subjected to steam distillation to remove the last traces of toluene. An oil is obtained which soon solidifies to a yellow mass this when crystallised from alcohol appears as white needles, sintering at 129° C., and melting at 134° to 135° C. It is readily soluble in cold chloroform and in hydrocarbons. 

IV-Methylation of polysubstituted pyridazinones is frequently accompanied by some side reactions, mainly substitutions. For example, methylation of 4-nitro-5,6-diphenyl-pyridazin-3(2//)-one with methyl iodide in the presence of sodium methoxide affords... 

The reaction of 3,5-diphenyl-2-isoxazoline with lithium diisopropylamide produced with 2 equivalents of base a chalcone oxime, while in the presence of 1 equivalent and an alkyl iodide, ring alkylation occurred at the 4-position of the nucleus (Scheme 48) (80LA80, 78TL3129). 

Tetrazolium iodide, l,3-dialkyl-5-phenyl-synthesis, 5, 815 Tetrazolium salts electrochemical reduction, 5, 73 hydrogen exchange, 5, 70 Tetrazolium salts, 2,3-diphenyl-5-oxide... 

Such methyenepyrans afford still another possibility for obtaining new pyrylium salts, namely, electrophilic alkylation or acylation at the exocyclio methylene carbon atom. Thus, 2,6-diphenyl-4-iso-propylidene-4/I-pyran is converted into 2,6-diphenyl-4-i-butyl-pyrylium iodide on refluxing with methyl iodide (see Scheme 3). Unlike the protonation of methylenepyrans, this reaction is no longer... 

The reaction of 78 with phosphorus pentasulfide in xylene gives the corresponding 2-oxazolethione, which also forms the iV -methyl product with dimethyl sulfate and 4,5-diphenyl-2-methyhnercapto-oxazole in 98% yield on treatment with silver oxide-methyl iodide. 

Tile same methodology as mentioned for the preparation of (9) was applied for the synthesis of 8-nitro-l,6-naphthyridines. Heating diethyl N- 3-nitropyridin-4-yl)aminomethylenemalonate (12) in diphenyl ether yields ethyl 8-nitro-l,6-naphthyridin-4(lH)-one 3-carboxylate (13) (63JCS4237, 30%) and acid treatment of 4-( y, y-diethoxypropylamino)-5-nitro-2-(/3,/3 -trifluoroethoxy)-pyridine (14) gives in a similar way 8-nitro-5-(/3, /3-triflu-oroethoxy)-l,2-dihydro-l,6-naphthyridine (15, 76%). Subsequent oxidation with chloranil, acid hydrolysis, and methylation with methyl iodide gives 8-nitro-6-methyl-l,6-naphthyridin-5(6H)-one (16,63%) (81JHC941). 

Like lV-methyl-2-phenylbenzothiazoliiim iodide (76KGS635), the salt 19 reacts with hydrazine hydrate to give 3,6-diphenyl-l,2-dihydro-l,2,4,5-tetrazine and di(o-lV-methylaminophenyl) ditelluride (92MI1). 

A chiral magnesium catalyst prepared from magnesium iodide and 1,2-diphenyl-ethylenediamine was also found to he effective in asymmetric aza Diels-Alder reaction of a-imino ester 21b with 7a (Scheme 5.12) [32]. The novel catalyst was discovered using parallel comhinatorial methods. 

A mixture of 84 parts of 3,3-diphenyl-3-cyanopropyl bromide, 41 parts of 4-piperidino4-pi-peridinecarboxamide, 64 parts of sodium carbonate, a small amount of potassium iodide and 1,200 parts of anhydrous toluene was stirred, and heated under reflux for 48 hours. At the end of this time the reaction mixture was allowed to cool to room temperature, and 500 parts of water were added. The resultant precipitate was removed by filtration, and triturated with diisopropyl ether. The crystalline material thus obtained was removed by filtration, and re-crystalli2ed from 320 parts of acetone, to give 1 -(3,3-diphenyl-3-cyanopropyl)4-piperidino-4-piperidinecarboxamide, melting at about 149°C to 150°C. 

Phosphine, diphenyl- [829-85-6], 45 Phosphine, tnphenyl- [603-35-0], 81 Phosphomum, [4-(4-methoxyphenyl)-2-butenyl] tnphenyl-, iodide [57620 96-9], 81... 

Carboxylic acids, a-bromination of 55, 31 CARBOXYLIC ACID CHLORIDES, ketones from, 55, 122 CARBYLAMINE REACTION, 55, 96 Ceric ammonium nitrate [Ammonium hexa mtrocerate(IV)[, 55, 43 Chlorine, 55, 33, 35, 63 CHROMIUM TRIOXIDE-PYRIDINE COMPLEX, preparation in situ, 55, 84 Cinnamomtnle, a-phenyl- [2-Propeneni-tnle 2,3-diphenyl-], 55, 92 Copper(l) iodide, 55, 105, 123, 124 Copper thiophenoxide [Benzenethiol, copper(I) salt], 55, 123 CYCLIZATION, free radical, 55, 57 CYCLOBUTADIENE, 55, 43 Cyclobutadieneiron tricarbonyl [Iron, tn-carbonyl(r)4-l,3-cyclo-butadiene)-], 55,43... 

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