2-Ethoxycarbonyl-4- -5-methyl- 4,6-Diphenyl

H5C6)2P-SNa Cl-CH2-COOC2H5 - Diphenyl-.. (ethoxycarbonyl-methyl-ester) 63 Ol 1011... 

R1 = COOC2H5, R2 = C6H5 Diphenyl-(ethoxycarbonyl-phenylhydrazono-methyl)-phosphanoxid ... 

Benzyl-diethoxy- E2, 134 Benzyl-diisopropyloxy- E2, 134 Benzyl-ethyl-phenyl- -tosylimid E2, 113 Benzyl-methyl-phenyl- -tosylimid E2, 113 Benzyloxy-diphenyl- E2, 17, 18 Benzyloxy-ethoxy-hydroxy- E2, 187 Bis-[2-biphenylyl]- E2, 876 [2,6-bis-(2-tetrahydropyranyloxy-methyl)-phenyl]-Bis-[4-brom-anilino]-phenyl- E2, 416 Bis-[2-brom-ethoxy]-(2-brom-ethyl)- E2, 196 Bis-[butylthio]-ethyi- E2, 79, 408 Bis-[2-chlor-cthoxy]-butyl- E2, 196 Bis-[2-chlor-ethoxy]-(2-chlor-ethyl)- E2, 196 Bis-[2-chlor-ethoxy]-methyl- E2, 196 Bis- 2-chlor-ethoxy]-phenyl- E2, 196, 197, 202 Bis- 2-ehlor-ethoxy]-(2-phcnyl-vinyl)- E2, 196 Bis-(2-ehlor-ethoxy]-vinyl- E2, 196 Bis-j 2-chlor-ethyl]-methyl- E2, 205 Bis-[chlormethyl]-dodecyl- E2, 22 Bis-12-cyan-ethyl]- E2, 223 Bis- diethylamino]-butyl- E2, 486 Bis-[ l-cthinyl-butyl]-phenyl- E2, 197 Bis-[ethoxycarbonyl-methyl]-chlor- E2, 251 Bis-[ethylthio]-ethyl- E2, 408 Bis-[4-methoxy-aniliiio]-phenyl- E2, 416 Bis-[4-methyl-phenylJ-phenyl- K2, 105 Bis- 4-methyl-phcnyl]-phenyl- -phenylsulfonvlimid E2, 105... 

Diphenyl-2-methyl- 144, 209, 878 5-Ethoxycarbonyl- 878 9-Methoxycarbonyl- 878, 1147 9-Methoxycarbonyl-5-methoxy- 878 9-Methoxycarbonyl-7-methoxy- 1148 9(7)-Methoxy-7(9)-methyl- 1184 9-Methyl- 1147... 

Ethoxycarbonyl-l,3-dimcthyl-4-hydroxy- 518 5-Ethoxycarbonyl-l,3-diphenyl-4-hydroxy- 518 l-Ethoxycarbonyl-4-(ethoxycarbonyl-methyl-... 

Selenophene, 2,5-dimethyl-3-mercapto-synthesis, 4, 956 tautomerism, 4, 946 Selenophene, 2,4-diphenyl-synthesis, 4, 135 Selenophene, 2,5-diphenyl-lithiation, 4, 949 UV spectra, 4, 941 Selenophene, 2-ethoxycarbonyl-mercuration, 4, 946 Selenophene, halo-reactions, 4, 955 Selenophene, 2-hydroxy-Michael reaction, 4, 953 tautomerism, 4, 36, 945, 953 Selenophene, 3-hydroxy-tautomerism, 4, 36, 945 Selenophene, 3-hydroxy-2,5-dimethyl-tautomerism, 4, 945, 953 Selenophene, 2-hydroxy-5-methyl-methylation, 4, 953 tautomerism, 4, 945 Selenophene, 2-hydroxy-5-methylthio-tautomerism, 4, 945 Selenophene, 3-iodo-synthesis, 4, 955 Selenophene, 3-lithio-reactions, 4, 79 synthesis, 4, 955 Selenophene, 2-mercapto-tautomerism, 4, 38 Selenophene, 3-mercapto-tautomerism, 4, 38 Selenophene, 2-mercapto-5-methyl-synthesis, 4, 956 tautomerism, 4, 946 Selenophene, 3-methoxy-lithiation, 4, 949, 955 synthesis, 4, 955 Selenophene, methyl-oxidation, 4, 951 synthesis, 4, 963 Selenophene, 2-methyl-lithiation, 4, 949 Selenophene, 3-methyl-synthesis, 4, 963... 

The Jacobs-Gould intramolecular cyclization of diethyl N-(6-methyl-2-pyridyl)amino-methylenemalonate to 3-ethoxycarbonyl-7-methyl-l,8-naphthyrid-4-one is another reaction ideally suited to microwave heating, although conductively heated equipment was employed for laboratory-scale experiments [45]. The product is a key intermediate in the synthesis of nalidixic acid, the first of the quinolone antibacterials. The process usually is conducted at temperatures of 200-250 °C and in high dilution, with heat transfer oils such as the eutectic mixture of diphenyl ether and biphenyl. However, it proceeded rapidly, predictably and controllably under solvent-free conditions. 

Other chemical reagents that have been used to dehydrogenate are diphenyl disulfide for 1,2,3,4-tetrahydrocarbazole itself, N-bromosuccinimide in pyridine for 1-ethoxycarbonyl-1,2,3,4-tetrahydrocarbazole, selenium dioxide for 9-methyl-1,2,3,4-tetrahydrocarbazole (a 1 5 mixture of 9-methyl-carbazole and 1-oxo-1,2,3,4-tetrahydrocarbazole was obtained ), and manganese dioxide to aromatize 1-methyl- and l,4-dimethyl-6-alkoxy-3-formyl-1,2,3,4-tetrahydrocarbazoles and 1,9-diprenyl-1,4-dihydrocarba-zole. ... 

Reaction of the 2-acetoxy-3(2//)-furanones (526) with monosubstituted hydrazines gives good yields of the pyridazinium-5-olates (527) together with varying amounts of isomeric products. Alkyl derivatives (527 R = alkyl) have also been prepared by base-catalyzed alkylation (Mel, Me2SO4, PhCH2Cl) of 3-methyl-6-phenyl-5-ethoxycarbonyl-4( 1 //)-pyridazinone. Reduction of the diphenyl compound 527 (R = Ar = Ph) by zinc and hydrochloric acid gives 3-ethoxycarbonyl-5-hydroxy-5-methyl-l,2-diphenyl-2-pyrrolin-4-one (528 R = Ar = Ph) (Scheme 21... 

Diazo-ethoxycarbonyl-mcthyl)-diphenyl- E2, 220 f l-Diazo-2-(2-furyl)-2-oxo-ethy[]-diphenyl- El, 592 (Diazo-methyl)-diphenyl- El, 586f, E2, 145, 220 (l-Diazo-2-oxo-2-phenyl-ethyl)-diphenyl- El, 593... 

Benzol- -dimcthylester El, 5/3 E2, 374 Benzol- -diphenylester Xll/l, 418, 426 E2, 381 Benzol- -(l,2-diphenyl-2-oxo-ethyIester) El, 54 Benzol- -dipiperidid Xll/l, 537, 597 Benzol- -dipiperidid-(4-nitro-phenylimid) E2, 482 Benzol- -divinylester XII/1, 429 Benzol- -(2-ethoxycarbonyl-l-methyl-vinylester)-methylester... 

UV spectra of substituted 1,3,4-oxadiazoles are similar to those of similarly substituted benzenes, particularly in the case of 2-phenyl- and 2,5-diphenyl-l,3,4-oxadiazole (Amax (EtOH) 247.5 nm, log e 4.26, and 280 nm, log e 4.44 respectively). However, no absorption above 200 nm is shown by 1,3,4-oxadiazole itself and calculated values (Section 4.23.2.1) for its long wavelength absorption are in the region of 200 nm compared with Amax ca. 260 nm for benzene. 2-Methyl- and 2-ethoxycarbonyl-l,3,4-oxadiazole, and A2-l,3,4-oxadiazoline-5-thione have the following Amax (log e) values respectively 206 nm (2.62) (methanol), 243 nm (3.2) and 260 nm (4.12) (ethanol). 

The following esters have been used 2-methoxycarbonyl (aq. NaOH/MeOH) (1263) 2-methoxycarbonyl-5-phenyl (85% KOH) (352) 2,5-diethoxycarbonyl-3,6-dimethyl (KOH) (18, 674) 2-chloro-3-methoxycarbonyl (K2CO3 or NaOH/ reflux) (838) 2-chloro-3-methoxycarbonyl-5,6-diphenyl (NaOMe/MeOH/reflux) (837) 5-ethoxycarbonyl-2,3-bis(5 -nitrofur-2 -yl) and its 6-methyl derivative (50% Ac0H/H2S04/reflux) (338) 2-amino-5-bromo-3-methoxycarbonyl (NaOH/reflux) (798) 2-amino-5,6-dichIoro-3-methoxycarbonyl (NaOH/reflux) (378a, 782, 809) 2-cyclohexylamino-3-methoxycarbonyl (NaOH/EtOH/reflux 1 h) (946) 2-(2, 3 -dimethylphenylamino)-3-methoxycarbonyl (NaOH/EtOH/reflux) (950) 2-amino-... 

Ben7yloxycarbonyl-6-[2-(5-bcn7yl-oxycarbonyl-5-ethoxycarbonyl-4-methyl-2-pyrrolyl)-l-isopropyl-4-imidazolyI]-2,3-diphenyl-1 -ethoxycarbonyl-5-methyl-4-oxo-3046... 

Diphenyl-l, 1,2,2-tetrachloro- 639 2-Ethenyl-l-methylen- 1699, 2305 1-Ethoxycarbonyl- 1243, 2503 4-Ethoxycarbonyl-l-methyl- 2503... 

Diphenyl-4-methoxycarbonyl-2-oxo- 2139 4-Ethoxycarbonyl-6-methyl-3-oxo- 2111 4-Methoxycarbonyl-3-methyl-2-oxo- 2139 4-Methylen-l-oxo- 2275... 

Propin-1 -phosphonsaure-diethylester addiert Diazo-essigsaure-ethylester (Verwendung eines 10%igen Uberschusscs) zu 3(5)-Diethoxyphosphoryl-5(3)-ethoxycarbonyl-4-methyl-lH-pyr-azol (58%) analog reagieren Propin-1-phosphonsaure-dichlorid, Diphenyl-(l-propinyl)- und Diethyl-( 1 -propinyl)-phosphanoxid1197. 

Brom-2,4-diphenyl- 239 2-Brom-4-ethoxycarbonyl- 275 2-Brom-5-ethoxycarbonyl- 274 2-Brom-5-ethoxycarbonyl-4-methyl- 275... 

Aeetyl-3,5-dimethyl-1 -(4-nitro-phcnyl)- 515 4-Acetyl-3,5-dimethyl-l-phenyl- 625 4-Acetyl-l, 3-diphenyl- 533, 536 3(5)-Acetyl-5(3)-ethoxycarbonyl-4-methy 1- 510 4-Acetyl-l-ethoxycarbonyl-3-methyl- 483 4-Acetyl-l-cthoxycarbonyl-5-methyl- 483 3(5)-Acetyl-4-ethoxycarbonyl-5(3)-phenyl- 524 l-Acetyl-4-cthyl- 613 4-(l-Acetyl-ethyl)-3,5-dimcthyl- 526 1 -Acetyl-3-fluor- 613... 

Chlor-phenyl)-l,4-diphenyl- 496 l-(3-Chlor-phenyl)-4-ethoxycarbonyl-5-iod- 644 1-(4-Chlor-phenyl)-4-ethoxycarbonyl-5-iod- 644 l-(4-Chlor-phenyl)-3-ethoxycarbonyl-5-(4-methoxy-phenyl)- 424, 481 l-(3-Chlor-phenyl)-4-ethoxycarbonyl-5-methyl-3-(3-nitro-phcnyl)- 517... 

Trimcthyl- 408 4H-Pyrazol 409 i 3 4- (4-Brom-phenyl)-l-(4,5-diphenyl-l,3-thiazol- 2-yl)-2-oxo-2,3-dihydro- 68 5- Ethoxycarbonyl-4-mercapto-l-methyl- 339 5-Mercapto- 339 1-Methyl- 710 l-Methyl-2-(2-phenyl-4-trifluormethyl-1,3-thiazol-5-yl)- 293... 

Bis-[2-(5-ethoxycarbonyl-4-methyl-l,3-thiazol-2-ylJ-hydrazino]- 332 2,2 -Bis-[phthalimido]- 258 2,2 -Diamino- 189 2,2 -Dianilino-4,4 -diphenyl- 189... 

---