Diphenyl amine Reagent

Reagent 1 Spmy solution 1 Dissolve 1 g iron(III) chloride and 1 g diphenyl-amine in 100 ml cone, sulfuric acid. 

Method. Place 1 drop of a solution of the sample on a filter paper, add 1 drop of the reagent, and expose the paper to hydrochloric acid fumes. Indications. An orange colour indicates the presence of an aromatic primary amine in which the amino group is attached directly to a benzene ring. An anomalous reaction is obtained with diphenyl-amine (bright orange). 

N-Alkylation of secondary amine takes place under sonication in the presence of a PTC reagent, polyethylene glycol monomethyl ether. SimilarlyN-alkylation of diphenyl amine is accomplished under sonication (Scheme 10). 

Diphenylamine (reagent for rayon). Dissolve 0.2 g diphenyl-amine in 100 mL of concentrated sulfuric acid. 

Both dimethyl carbonate [616-38-6] and diphenyl carbonate [102-09-0] have been used, in place of carbon monoxide, as reagents for the conversion of amines into isocyanates via this route (28,29). Alternatively, aniline [62-53-3] toluene diamines (I JJA), and methylene dianilines (MDA) have also been used as starting materials in the carbonylations to provide a wide variety of isocyanate monomers. 

The procedure described is essentially that of Shioiri and Yamada. Diphenyl phosphorazidate is a useful and versatile reagent in organic synthesis. It has been used for racemlzatlon-free peptide syntheses, thiol ester synthesis, a modified Curtius reaction, an esterification of a-substituted carboxylic acld, formation of diketoplperazines, alkyl azide synthesis, phosphorylation of alcohols and amines,and polymerization of amino acids and peptides. - Furthermore, diphenyl phosphorazidate acts as a nitrene source and as a 1,3-dipole.An example in the ring contraction of cyclic ketones to form cycloalkanecarboxylic acids is presented in the next procedure, this volume. 

The fluoride [NS(0)F]3 is more stable thermally and towards nucleophilic reagents than the corresponding chloride. For example, 8.15a is hydrolyzed by water to NH(S02NH2)2, whereas sulfanuric fluoride is unaffected by cold water. In warm water, however, hydrolysis occurs to give the [N3S304F2] anion. All three fluorine atoms in [NS(0)F]3 can be replaced by primary or secondary amines at 80-90°C in the absence of a solvent. Mono- or diphenyl derivatives can be prepared by treatment of [NS(0)F]3 with PhLi in diethyl ether at -70°C, while the Friedel-Crafts reaction with benzene at reflux in the presence of AICI3 gives two isomers of [NS(0)Ph]3. ... 

Carboxylic acids can also be activated by the formation of mixed anhydrides with various phosphoric acid derivatives. Diphenyl phosphoryl azide, for example, is an effective reagent for conversion of amines to amides.140 The proposed mechanism involves formation of the acyl azide as a reactive intermediate. 

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