Dipeptides molecular recognition

Molecular Recognition of Crystalline Dipeptides and Its Application to Separation... 

X. Cha, K. Ariga, M. Onda, T. Kunitake, Molecular Recognition of Aqueous Dipeptides by Noncovalendy Aligned Oligoglycine Units at the Air/Water Interface , J. Am. Chem. Soc., 117, 11833 (1995)... 

Swaan, P.W., Bensman, T., Bahadduri, P., Hall, M.W., Sarker, A., Ekins, S. et al. (2008) Bacterial dipeptide recognition and immune activation facilitated by the human peptide transporter PEPT2. American Journal of Respiratory Cell and Molecular Biology, 39 (5). 536-542. 

Gresh, N., Guo, H., Salahub, D. R., Roques, B. P, and Kafafi, S. A. Critical role of anisotropy for the dimerization energies of two protein—protein recognition motifs Cis-N-methylacetamide versus a /3-sheet conformer of alanine dipeptide. A joint ab initio, density functional theory, and molecular mechanics investigation./. Am. Chem. Soc., 121, 7885-7894, dol 10.1021/ja9742489 (1999). 

In the same line of thought, Lehn and Sirlin (148) have prepared a chiral macrocyclic molecular catalyst bearing cysteinyl residues. The catalyst complexes primary ammonium salts and displays enhanced rates of intramolecular thiolysis of the bound substrates with structural selectivity for dipeptide esters and high chiral recognition for the L-enantiomer (70 times faster) of a racemic mixture of glycylphenylalanine p-nitrophenyl esters. The representation below shows the complex between the chiral crown ether and the dipeptide glycylglycine p-nitrophenyl ester salt. 

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