Dioxygen coordination chemistry

To better understand copper-dioxygen coordination chemistry with varying ligand type, Karlin and co-workers synthesized and investigated spectroscopic and redox properties of many complexes (218) (t= 1.005) and (219) (r = 0.19), (220) (t = 0.50),209 (221) (r = 0.19) and (222)... 

Copper(II) complexes with phenoxo ligands have attracted great interest, in order to develop basic coordination chemistry for their possible use as models for tyrosinase activity (dimeric complexes) and fungal enzyme galactose oxidase (GO) (monomeric complexes). The latter enzyme catalyzes the two-electron oxidation of primary alcohols with dioxygen to yield aldehyde and... 

There has been enormous activity in the field of copper(I)-dioxygen chemistry in the last 25 years, with our information coming from both biochemical-biophysical studies and to a very important extent from coordination chemistry. This has resulted in the structural and spectroscopic characterization of a large number of copper dioxygen complexes, some of which are represented in Figure 14.2. The complex F, first characterized in a synthetic system was subsequently established to be present in oxy-haemocyanin, and is found in derivatives of tyrosinase and catechol oxidase, implying its involvement in aromatic hydroxylations in both enzymes and chemical systems. 

Hni HAO, Tew DG (1987) Dioxygen, Peroxide and Superoxide. In Wilkinson G, Gillard RD, McCleverty JA (eds) Comprehensive Coordination Chemistry, vol 2, chap 15.2. Pergamon Press, Oxford, p 315... 

We have seen a quantum leap in progress in the coordination chemistry of copper-dioxygen interactions, resulting in a complete change in thinking about Cu202 structure and related protein chemistry. The problems of copper ion lability, peroxide disproportionation and air/moisture sensitivity have been overcome, and it has been proved that low-molecular-weight Cu 02 or Cu (0)2 complexes can be prepared, and that several different structural types exist. It is apparent that u-r 2 r 2-peroxo coordination is present in oxy-Hc and oxy-Tyr. 

Cobalt Inorganic Coordination Chentistry Copper Hemocyanin/Tyrosinase Models Copper Inorganic Coordination Chemistry Copper Proteins Oxidases Copper Proteins with Dinuclear Active Sites Iron Heme Proteins Dioxygen Transport Storage Iron Heme Proteins, Mono- Dioxygenases Iron Models of Proteins with Dinuclear... 

Dioxygen Related Ligands Iron Heme Proteins, Peroxidases, Catalases Catalase-peroxidases Nitrogenase Catalysis Assembly Vanadium Inorganic Coordination Chemistry Vanadium OrganometaUic Chemistry. 

Bertini, Ivano, Russell S. Drago, C. Luchinat, and North Atlantic Treaty Organization Scientific Affairs Division. The Coordination Chemistry of Metalloenzymes The Role of Metals in Reactions Involving Water, Dioxygen, and Related Species. Proceedings of the NATO Advanced Study Institute, held at San Miniato, Pisa, Italy, May 28-June 8, 1982. Boston D. Reidel, 1983. 

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