Dinitrobenzoyl-methylbenzylamine

Dawson et al. presented a study using different reagents, such as a-, 3-, and y-CDs, S-a-methylbenzylamine, (R)-A -3,5-dinitrobenzoyl-methylbenzylamine, (S)-1 -(1 -naphthyl)-ethylamine and (R)-2,2,2-trifluoro-l-(9-anthrylethanol) (R-TFAE), for enantiomeric evaluation of the dissolution of ketoprofen (Figure 6-7) formulations [8]. 

This material was then used as the stationary phase in the separation of a racemic mixture of 3,5-dinitrobenzoyl-a-methylbenzylamine. Separation of this mixture is a common test to measure the separating ability of a CSP. In our test, CSP-1 was able to distinguish between the R and S enantiomers, but did not provide baseline separation. This may be due to the... 

Based on chiral functional monomers such as (15) in Table 5.6C MIPs capable of chiral resolution can be prepared using a racemic template. Thus, using racemic N-(3,5-dinitrobenzoyl)-a-methylbenzylamine (16 in Table 5.6C) as template, a polymer capable of racemic resolution of the template was obtained [86]. Another chiral monomer based on L-valine (17) was used to prepare MIPs for the separation of dipeptide diastereomers [94]. In these cases, the configurational chirality inherent in the pendant groups of the polymer are to some extent themselves chiral selectors and the effect of imprinting is merely to enhance the selectivity. Alternative approaches to imprint peptides via strong monomer-template association have recently been... 

Fig. 17.12. Separation of 3.2 nmol of racemic lV-(3,5-dinitrobenzoyl)-a-methylbenzylamine on poly((5)-(-)-methacryloyl-l-naphtylethylamine-co-EDMA) prepared by a two-step swelling and polymerisation method using racemic A-(3,5-dinitrobenzoyl)-a-methylbenzylamine as template. Isocratic elution at 1 mL/min with hexane-ethyl acetate (1 1). (Adapted from [55], with permission from the American Chemical Society, USA.)...

Fig. 14 Chromatographic separation of the two enantiomers of AT-(3,5-dinitrobenzoyl)-a-methylbenzylamine (DNB) on networks imprinted around (S)-DNB. Effect of the mode of preparation on the chromatographic properties (1) imprinted beads of uniform size (Fig. 12(2)) (2) ground graded MIP (Fig. 12(1)) (from [114])...

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