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Dimethylformamide metabolism

Differences between rodents and humans in the metabolic toxification of N,N-dimethylformamide. Toxicol Appl Pharmacol 98 507-516, 1989... [Pg.267]

Figure 4.17 Metabolism of dimethylformamide. The hydroxymethyl derivative is stable but may subsequently rearrange to monomethylformamide with release of formaldehyde. Figure 4.17 Metabolism of dimethylformamide. The hydroxymethyl derivative is stable but may subsequently rearrange to monomethylformamide with release of formaldehyde.
Dimethylformamide inhibited intercellular communication (as measured by metabolic co-operation) between Chinese hamster V79 hprt cells. [Pg.564]

Chieli, E., Saviozzi, M., Menicagli, S., Branca, T. Gervasi. PG. (1995) Hepatotoxicity and P-4502E1-dependent metabolic oxidation of. V.Y-dimethylformamide in rats and mice. Arch. Toxicol.. 69, 165-170... [Pg.566]

Imazu, K., Fujishiro, K. Inoue, N. (1992) Effects of dimethylformamide on hepatic microsomal monooxygenase system and glutathione metabolism in rats. Toxicology, ll. 41-50... [Pg.568]

Mraz, J. Nohova, H. (1992b) Absorption, metabolism, and elimination of W-dimethylformamide in humans. Int. Arch, occup. environ. Health, 64, 85-92... [Pg.570]

Van den Bulcke, M., Rosseel, M.T., Wijnants, R, Buylaert, W. Belpaire, F.M. (1994) Metabolism and hepatotoxicity of ALV-dimethylformamide, V-hydroxymethyl-V-methylforma-mide, and V-methylformamide in the rat. Arch. Toxicol., 68, 291-295... [Pg.573]

Ethanol Ethanol (OES 1000 ppm 8h TWA) has well-known effects on the CNS and can cause irritation. Although metabolised to acetaldehyde and acetate, ethanol appears to have little ability to cause chronic toxic effects at exposure levels likely to be encountered in reasonable industrial and laboratory use. It should be noted that ethanol may compete with other substances present in the workplace atmosphere for the oxidative enzyme systems involved in this metabolism, thereby inhibiting their metabolism or excretion and increasing their toxic effects. This may occur with a number of solvents including trichloroethylene, xylene, benzene and dimethylformamide. The presence of denaturants (e.g. methanol, pyridines) greatly increases the toxicity of ethanol by ingestion and may also present a hazard by the inhalation route. [Pg.92]

See other pages where Dimethylformamide metabolism is mentioned: [Pg.551]    [Pg.226]    [Pg.551]    [Pg.226]    [Pg.89]    [Pg.551]    [Pg.551]    [Pg.552]    [Pg.556]    [Pg.567]    [Pg.570]    [Pg.585]    [Pg.383]    [Pg.160]    [Pg.509]    [Pg.61]    [Pg.350]   
See also in sourсe #XX -- [ Pg.89 ]



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Dimethylformamide

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