Dimethylcarbamoylation

Otherwise cyanoacetic acid is directiy converted as a solution with 1,3-dimethylurea [96-31-1] iato 2-cyano-A/,AT-dimethylcarbamoyl acetamide [39615-79-7] which is further upgraded iato the diuretics theophylline [58-55-9] (33 where R = H) and caffeiae [58-08-2] (33, where R = CH3) (63). 

Acidimetric, spectrophotometric and HPLC assays were developed for determination of 2,3,5,6,7,8-hexahydro-l//-pyrido[l,2-c]pyrimidine-l,3-diones 135 (98M133). Its solubility properties were also characterized. Resolution of the enantiomers of 4-phenyl-2- 4-[4-(2-pyrimidinyl)piperazi-nyl]butyl perhydropyrido[l,2-c]pyrimidine-l,3-dione was achieved on hep-takis(2-N, V-dimethylcarbamoyl)- 6-cyclodextrines (01 JC(A)249). 

Beryllium and certain compounds Cadmium and certain compounds Carbon tetrachloride Chlorambucil Cyclophosphamide Dimethylcarbamoyl chloride Dimethyl sulphate Ethylene oxide Iron dextran... 

Amino-3-(A,iV-dimethylcarbamoyl)thiopyridine was reacted with EMME or di-(4-methoxybenzyl) (4-methoxybenzyloxy)methylenemalo-nate at 100-120°C for 1 hr to afford 2-pyridylaminomethylenemalonates (50) in 76 and 80% yields, respectively (86EUP218423). 

The reaction of 4-lithiodibenzofuran with 0-methylhydroxylamine provides a synthesis of the 4-amino compound, and reaction with iodine leads to the iodo compound. The reactions of 4-lithiodibenzofuran with tributyl borate,diphenyl disulfide, A,A/-dimethylcarbamoyl chloride, and cyanuric chloride have been studied. 

Pyridol, Pyrrolidine, Formaldehyde, Pyridine, Dimethylcarbamoyl chloride. Sodium carbonate. Chloroform, Sodium sulfate. Sodium sulfate, Tetrahydrofuran, fl,fl -Dibromo-4,4 -biacetophenone, Ethanol, Charcoal, Ethyl ether Ethyl alcohol, 3-Dimethylcarbomoxydunethylanaline, Dibromo-4,4 -biacetophenone, Charcoal, Ethyl acetate Bleach, Ammonia... 

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