3-Dimethylamino-2,5-dimethylpyrazine

Chlorination of 2-methylpyrazine in acetic acid at 100° gave 2-trichloromethyl-pyrazine (685, 686), whereas 2-chloro-3-methylpyrazine under similar conditions gave 2-chloro-3-dichloromethylpyrazine (685, 687, 688). Chlorine bubbled into a stirred solution of 3-dimethylamino-2,5-dimethylpyrazine in chloroform gave the 6[Pg.80]

Chloro-5-dimethylamino-3, 6-difluoropyrazine 2-Chloro-6-dimethylamino-3, 5-difluoropyrazine 2-Chloro-5-dimethylamino-3, 6-diisobutylpyrazine 2-Chloro-5-dimethylamino-3,6-diisopropylpyrazine 2-Chloro-5-dimethylamino-3,6-dimethylpyrazine 2-Chloro-6-dimethylamino-3,5-diphenylpyrazine... 

Dimethylamino-5,6-dimethyl-2-pyrazinamine 2-Dimethylamino-3,6-dimethylpyrazine 2-Dimethylamino-5,6-dimethylpyrazine... 

Dimethylamino-7V-hydroxy-2-pyrazinecarboxamide 6-Dimethylamino-7V-hydroxy-2-pyrazinecarboxamidine 2-Dimethylamino-5-iodopyrazine 2-Dimethylamino-6-iodopyrazine 2-Dimethylamino-5-iodopyrazine 4-oxide 2-Dimethylamino-3-isobutylpyrazine 2-Dimethylamino-6-isobutylpyrazine 2-Dimethylamino-5-methoxy-3,6-dimethylpyrazine 2-Dimethylaminomethyl-3,6-bismethylthiopyrazine 2-Dimethylamino-6-methyl-5-phenylpyrazine 4-oxide 2-Dimethylamino-3-methylpyrazine 2-Dimethylamino-6-methylpyrazine 2-Dimethylamino-3-methylpyrazine 4-oxide Dimethyl 5-amino-6-oxo-1,6-dihydro-2,3-pyrazinedicarboxylate 2-Dimethylamino-5-phenylpyrazine 2-(3-Dimethylaminopropyl)-6-methylpyrazine... 

Dimethylamino-23-dimethylpyrazine 1-oxide in boiling acetic anhydride gave 2-acetoxymethyl-3-dimethylamino-5-methylpyrazine (793) which was not isolated but saponified directly to 3-dimethylamino-2-hydroxymethyl-5-methylpyrazine (793). 2-Amino-3-cyano-5-methylpyrazine 1,4-dioxide refluxed with (a) acetic anhydride gave 3-acetamido-2-cyano-5-hydroxy-6-methylpyrazine 1-oxide (532) and (6) sodium methoxide gave 3-amino-2-cyano-5-methoxy-6-methylpyrazine 1-oxide (532). 

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