Dimethylallyl pyrophosphate: tryptophan dimethylallyltransferase

Dimethylallyl pyrophosphate L-tryptophan dimethylallyltransferase, chanoclavine-I-cyclase (D 21.2) Agroclavine, elymoclavine, lysergic acid I. R ... [Pg.54]

One example where product inhibition obviously plays a role in living cells is ergoline alkaloid formation in Claviceps (D 21.2). In mycelial mats of Claviceps developing in stationary batch cultures the intracellular concentration of ergoline alkaloids and the activity of dimethylallyl-pyrophosphate L-tryptophan dimethylallyltransferase (DMAT synthase) measurable in homogenates undergo fluctuations Enzyme activity tends to decrease when the intracellular alkaloid concentration is at a maximum. This oscillation may be explained by... [Pg.55]

Dimethylallyl pyrophosphate L-tryptophan dimethylallyltransferase (DMAT synthase) ... [Pg.397]

Dimethylallyltryptophan synthetase (systematic name dimethylallyl-pyrophosphate L-tryptophan dimethylallyltransferase) was isolated by Heinstein et al. (1971). The enzyme was purified to homogeneity from mycelia of Claviceps strain SD 58 (Lee et al., 1976). The enzyme is a single polypeptide chain with molecular weight 73,000. It is activated by... [Pg.57]