Dimethyl sulphoxide toxicity

Toxicity. Dimethyl sulphoxide has low systemic toxicity, but gives local toxic effects. 

It is important that the solvent in which the protein is dissolved has a high solvent power for the protein, preferably be soluble in the SF of choice and be compatible with the protein. Organic solvents such as dimethyl sulphoxide and dimethyl formaldehyde have been used because they meet the criteria of salvation of the protein and solubility in SFCO. However, toxicity and compatibility of these solvents with protein molecules remain an issue [18]. 

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