3.5- Dimethyl-4-amino- 1,2,4-triazole

A triazole-bridged cadmium coordination polymer, based on 3,5-dimethyl-4-amino-1,2,4-triazole, has been synthesized under hydrothermal conditions [17]. This material exhibits a strong blue fluorescence emission band in the solid state at ambient temperature. 

V-[[l-[4-chloro-2-(2-chlorobenzoyl)phenyl]-3-[(dimethyl-amino)carbonyl]-l/f-l,2,4-triazol-5-yl]methyl]-l,3-dihy-dro-l,3-dioxo-2H-isoindole-2-acetamide (C29H22CI2NSO5 65699-00-5) see Rilmazafone... 

Cyclopropan 1-Azido-l-dimethyl-amino- E17b, 1593 (OH - N3) Guanidin 4-Cyan-l-propyl- E4,1299 (OR - NH-C3H7) lH-Tetrazol 1-Butyl- E8d, 679 [HC(OR)3 + R-NH2/NaN3] 4H-1,2,4-Triazol... 

AMINO-3-PHENYL-1-BIS (DIMETHYL-AMINO)-PHOSPHORYLE-1,2,4-TRIAZOLE (FRENCH) see AIXOOO... 

German names 3-Azido 3 f4 dimethyl-amino-l-henzol)-azo]-triazol-1.2,4 of Azido-3[(dime thy lamido-4-benzol-l -azoy3-triazol-1.2,4... 

Pyrazolino[2,3-c][l,2,3]triazoles, 5, 702 Pyrazolium hydroxide, l,2-dimethyl-3,5-diphenylanhydro-4-hydroxy-IR spectra, 5, 201 Pyrazolium salts dequatemization, 5, 269 H NMR, 5, 185 hydrogen exchange at ring carbon, 5, 245 mesoionic compounds, 5, 171 nitrodebromination, 5, 237 reactivity, 5, 217 reduction, 5, 68, 243 synthesis, 5, 156 UV spectra, 5, 199 Pyrazolium salts, amino-reactions, 5, 262 Pyrazolium salts, bromo-nucleophilic displacements, 5, 266 Pyrazolium salts, 1,2-dimethyl-deuteration, 5, 175, 245 hydrogen exchange, 5, 71 acid-catalyzed, 5, 239 reactions... 

Diazotized 3-amino[l,2,4]triazole reacted with 1,3-cyclohexanedioneor its 5,5-dimethyl derivative and 1,3-indanedione to give (76M1199) tricyclic... 

Arylazo-4-(3-ethoxycarbonylureido)furoxans 62, which were synthesized by the reactions of 4-amino-3-arylazo-furoxans with ethoxycarbonyl isocyanate, were subjected to cascade rearrangements under the action of potassium r/-butoxidc in dimethylformamide or by heating in dimethyl sulfoxide to form 4-amino-2-aryl-5-nitro-2//-l,2,3-triazoles 63 (Scheme 13) <2001MC230, 2003RCB1829>. 

Similarly, the reaction of 4-amino-l-mcthyl-3-methylthio-l//-[l,2,4]tnazol-5(4//)-onc 116 furnishes 6-aryl-2-methyl-7//-[l,2,4]triazolo[4,3-/d[l,2,4]triazol-3(2//)-ones 117 (Equation 32) <1985BCJ735> and the 4-amino[l,2,4]triazole-5(4//)-thione 118 furnishes 6-aryl-l,3-dimethyl-l//-[l,2,4]triazolo[4,3-3][l,2,4]triazoles 119 (Equation 33)... 

Deamination into 2,4,6-trimethylpyrimidine, together with a simultaneous formation of 3,5-dimethyl-l,2,4-triazole, occurs when A-amino-2,4,6-trimethylpyrimidinium mesitylenesulfonate reacts with liquid ammonia... 

In the reaction of o-azidoaniline with DMAD, it has been observed that both the amino and azido groups participate, giving rise to dimethyl 2-(4,5-dicarbomethoxy-l,2,3-triazol-l-yl)anilinofumarate (55) [Eq. (15)]. ... 

Zinc chloride-doped natural phosphate was shown to have catalytic behavior in the 1,3-dipolar cycloadditions of nucleoside acetylenes with azides to form triazolonucleosides <99SC1057>. A soluble polymer-supported 1,3-dipolar cycloaddition of carbohydrate-derived 1,2,3-triazoles has been reported <99H(51)1807>. 2-Styrylchromones and sodium azide were employed in the synthesis of 4(5)-aryl-5(4)-(2-chromonyl)-1,2,3-triazoles <99H(51)481>. Lead(IV) acetate oxidation of mixed bis-aroyl hydrazones of biacetyl led to l-(a-aroyloxyarylideneamino)-3,5-dimethyl-l,2,3-triazoles <99H(51)599>. Reaction of 1-amino-3-methylbenzimidazolium chloride with lead(fV) acetate afforded l-methyl-l/f-benzotriazole <99BML961>. Hydrogenation reactions of some [l,2,3]triazolo[l,5-a]pyridines, [l,2,3]triazolo[l,5-a]quinolines, and [l,2,3]triazolo[l,5-a]isoquinolines were studied <99T12881>. 

Amino-l,2,4-triazole was alkylated with 4-nitrobenzyl bromide by simply refluxing the mixture in isopropanol to give SO in excellent yield. The aminotriazole SO was deaminated with NaNOa in aqueous HCI and the nitro group was reduced with ammonium formate catalyzed by 10% Pd/C to deliver 47 in an improved yield over the route shown in Scheme 17. Diazotization of 47, reduction of the diazonium salt with sodium sulphite and Fischer indolization of the resulting hydrazine with 4-( /, /-dimethylamino)butanol dimethyl acetal was performed in a single step to afford rizatriptan (4) in 45% yield. 

Note Although this compd is not listed in the literature as an expl, it is included here because it is isomeric with l-amino-4,5 dimethyl-a-vic-triazole, which is an expl... 

Amino-, 5-dimethyl-1,2,4-triazole, listed as such in CA 28,26 79(1936), seems to be identical with 4-amino-3,5-dimethyl-4,l,2-triuZolvy listed in CA F or mu 13. Index 1020— 1946,p 61, bottom of right-hand column... 

Arrino-3,5-dimethyi>4H-l,2,4 triazole or 3,5-Dimethyl-4-amino-4,l,2-triozole,... 

Related to Scheme 42 was the reaction of 65 with dimethyl acetylene-dicarboxylate, which gave a mixture of 7-methyoxycarbonyl-l, 2,4-tria-zolo[4,3-o]pyrimidin-5-one (101), 7-methoxycarbonyl-l,2,4-triazolo[l,5-a]pyrimidin-5-one (102), and dimethyl (3-amino-l,2,4-triazol-l-yl)fumarate (103) (71CB2702) (Scheme 43). 

Diazacyanine dyes with two different alkyl substituents on the triazole nitrogen atoms are obtained by coupling diazotized 3-amino-1-benzyl-1,2,4-triazole to l-ethyl-2-phenylindole and quatemizing the azo dye with dimethyl sulfate or, in the acid pH range, with acrylamide to form the diazacyanine dye [104],... 

G2N3 N N N C c l,3-Dimethyl-4-(l,2,3-triazolyl)sulfide 3-methyl-2-phenyl-l,2,3-triazol-l-ine-4-thione 2-(4-chlorophenyl)-4-amino-5-benzoyl-l,2,3-triazoleaf... 

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