Dimethyl amino pyridine

Aranda and Burk [81] have established an SPME-HPLC-FL method and on-line derivatisation to determine AEs (Brij 56) in water. The surfactant was extracted with a PDMS-DVB fibre and pre-column derivatisation with 1-naphthoyl chloride in the presence of 4-(dimethyl-amino)pyridine as catalyst. The method has a limit of detection of 0.1 mg L-1. 

Methode 2,65 g (11 mmol) 4-Chlorcarbonyl-3,5-dioxo-4-aza-tricyclo[5 2.1.02-6]dec-8-cn lost man in 20 ml THF und kiihlt auf 0° ab. Zu dieser Losung wird bei 0° miter Riihren ein Gcmisch aus 10 mmol Carbonsaure-hydrazid, 30-50 ml THF, 869 mg (11 mmol) Pyridin und 3,66 mg (0,03 mmol) 4-Dimethyl-amino-pyridin (DMAP) zugetropft. Danach riihrt man 1 h bei 0 und 3 b bei 20". Nach Eincngen der Reaktionsmischung versetzt man mit 30 ml Wasser, riihrt 10 min, saugt ab und kristallisiert aus Ethanol um. 

The first base-stabilized silylene-bridged dinuclear complex has been synthesized by the exchange of an iodide ion on the iodosilylene-bridged complex to a strong Lewis base, JV-methylimidazole (NMI) or 4-(dimethyl-amino)pyridine (DMAP) [Eq. (30)].61,63... 

Nakane and Hutchinson have further shown that the aldol step in this cyclization is stereoselective as well as regioselective. Treatment of (39) with Hunig s base, acetic anhydride and 4-(A, A -dimethyl-amino)pyridine (DMAP), followed by sodium borohydride reduction of the intermediate P-hydroxy aldehyde, gives diol (40) in 48% yield no diastereomeric diols were detected (equation 102). 2i... 

The sulfonamide-derivatized support is readily prepared by treating amino-methylated resin with 4-carboxybenzenesulfonamide, N,N-diisopropylcarbodi-imide, and 1-hydroxybenzotriazole. Treatment of the sulfonamide resin with pentafluorophenyl active ester of 4-bromophenylacetic acid and 4-(dimethyl-amino) pyridine then gives the acylsulfonamide. Subsequent treatment of acylsulfonamide with excess LDA (15 equiv) in THF at 0 °C results in rapid deprotonation to give the trianion. 

Af,Af-dimethyl amino pyridine (DMAP), stored in a RT dessicator. 

An improved preparation of methyl 3-deoxy-3-fluoro-y9-D-galactopyran-oside using diethylaminosulphur trifluoride (DAST) and -(dimethyl-amino) pyridine has been described. 

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