3.4- dimethoxyphenyl phenyl

The notion of stabilized and sensitized protectors is pertinent to solid-phase synthesis in particular. Practically all of the linkers through which carboxy-terminal residues are attached to the solid support are composed of benzyl that has been substituted with functional groups such as dialkoxy, dimethoxyphenyl, phenyl (ben-zhydryl), diphenyl (trityl), chlorodiphenyl (chlorotrityl, see Section 5.23), or other to modify the stability of the linking bond.9-63-73... 

At the same time, Osterodt et al. (1994) published the structure of another substituted methanofullerene[60], namely that of (3,4-dimethoxyphenyl)phenyl-methanofullerene[60] (8.36, R and R = C6H5 and 3,4-(CH30)2C6H3, respectively). A [6,6]-closed structure was also found for this compound. 

Dimethyl-2,6-octadienyl)-2-hydroxy-4,6-dimethoxyphenyl]phenyl-methanone (E) (Marupone monomethyl ether)... 

Diethyi ((4-chioro-3-nitrophenyl)((3(phenylthio)- Diethyl ((4-hydroxy-3,5-dimethoxyphenyl)-phenyl)amino)methyl)phosphonate (54a, solid, mp ((3-(phenylthio)phenyl)amino)methyl)-94-95 C, time 6 min, yieid 93%) phosphonate (54a, solid, mp 94-95 °C,... 

Appendix - Phenyl acetones by electrolytic oxidation. Process for 3,4-dimethoxyphenyl-acetone preparation. European Patent Application 0247526, Filed 02.12.87 to LARK S.p.a. Milan. 

A solution of 20.7 g (0.1 mmol) of (46 ,56 )-5-amino-2.2-dimethyl-4-phenyl-l,3-dioxane and 19.4 g (0.1 mol) of 3,4-dimethoxyphenyl-2-propanone in 70 mL of CH3OH is warmed to 60 "C and 9 mL of acetic acid is added. After 15 min the mixture is cooled with an ice bath. The precipitated product is filtered off, stirred with 1 L of water for 1 h to dissolve inorganic salts, and again collected by filtration. Drying over NaOH and recrystallization from CH3OH gives the product yield 33.6 g (82%) mp 127 128°C [a] 2 + 85.7 (c = 1, CHC1,). 

Ethyl a-ACETYL-/3-(2,3-DiMETHOXY-phenyl)propionate, 31, 56 Ethyl a-acetyl-/3-(3,4-dimethoxyphenyl)-propionate, 31, 58... 

A chiral BDPP-Rh complex is an efficient catalyst for the hydrogenation of 3-(2, 4 -dimethoxyphenyl)-3-phenyl-2-propenol. The chiral alcohol product, with enantiomeric excess up to 95%, has been used for the synthesis of chiral 4-methoxydalbergione (Scheme 6).251,251a... 

Fig. 10.23 X-ray structure of [Rh((R,R)-Et-DuPHOS)((Z)-3-N-acetylamino-3-(phenyl)-methyl propenoate)]+ and of[Rh((S,S)-DIPAMP)((Z)-2-benzoylamino-3-(3,4-dimethoxyphenyl)-methyl acrylate)]+ [62],...

Verapamil Verapamil, 5-[(3,4-dimethoxyphenethyl)methylamino]-2-(3,4-dimethoxy-phenyl)isopropylvaleronitrile (19.3.15), is synthesized by a scheme nsing 3,4-dimethoxyphenylacetonitrile as the initial snbstance. The synthesis of the final prodnct (19.3.15) is accomplished by alkylating 2-(3.4-dimethoxyphenyl)-3-methylbntyronitrile (19.3.11) with V-[2-(3,4-dimethoxyphenyl)-ethyl]-iV-3-(chloropropyl)-iV-methylamine... 

A,4/ )-4-(3,4-Dimethoxyphenyl)-l,3-[Pg.800]

When compared to phenyl lithium, the addition of 2,6-dimethoxyphenyl lithium to 1,10-phenanthroline is more difficult [22]. But even the introduction of non-hindered lithium organic compounds to 2-phenylpyridine gives only small yields (a) Gilman H, Edwards JT (1953) Can J Chem 31 457 (b) Overterger CG, Lombardino JG, Hiskey R (1957) J Am Chem Soc 79 6430... 

An attempt to utilize this conversion of amines into aldehydes in an isoquinoline synthesis was not successful.439 Instead, reaction between 2-(3,4-dimethoxyphenyl)ethylamine and isatin afforded only the spiro compound 150.439 Reaction between isatin and 2-(3-hydroxy-4-methoxyphenyl)ethylamine gave a mixture of two spiro compounds, while a reaction of isatin, this amine, and benzylamine gave 6-hydroxy-7-methoxy-l-phenyl-1,2,3,4-tetrahydroisoquinoline.439... 

The syntheses of y-, a-, and IV-benzoinyl (y-, a-, and V-desyl) protected glutamic acid (129, 131, and 133, respectively, Scheme 34) and tert-butyl [l-(3,5-dimethoxyphenyl)-2-phenyl-ethoxyjcarbonyloxy) protected sarcosine ester (135, Scheme 35) are described below. 

The 13C spectra of several 1-phenyl-3,4-dihydro-, l-phenyl-l,2,3,4-tetra-hydro-, and 1-naphthyl-3,4-dihydroisoquinolines have been reported in the compilation of Shamma and Hindenlang (7). The chemical shifts that have been assigned to the isoquinoline moieties in these molecules agree with those of similar systems discussed in previous sections of this article. The chemical shifts of the carbon atoms in the 3,4-dimethoxyphenyl groups are remarkably similar to those of the same unit in laudanosine (28). In the 1-naphthyl series the spectra of three compounds differently substituted in the naphthalene unit were recorded and assignments made to all carbon atoms. 

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