4.7- dimethoxy-2-propyl

Auch funktionell substituierte 2-Amino-alkohole lassen sich so herslellen, 7. B, 3-[3-(Ben y oxymeihylJ-2-(3,3-dimethoxy-propyl)-cyclohexylamino]-4-hydroxy-lJ-hexadien (63%) aus2,3-Divinyl-oxiran und dem entsprechenden Aminodiethyl-alan ... 

Benzene, l-azido-3,3-dimethoxy-l-pro-penyl-[56900-67-5], 57, 84 Benzene, (l-azido-2-iodo-3,3-dimethoxy-propyl)- [56900-66-4], 57, 84 Benzene,bromo-, [108-86-1], 55,51 58, 135, 136, 138... 

C7H14O3S thioacetic acid S-(3,3-dimethoxy-propyl) ester 128352-00-1... 

Methyl and 6-methyl-5-n-propyl substituted 2,4-dimethoxy-pyrimidines react with methyl iodide, as does the simple dimethoxy compound, to give methoxypyrimidones, but the 6-chloro-2,4-dimethoxy derivative (47) is affected only at 100°, when it gives 4-chloro-1,3-dimethyluracil (48). ... 

CN ( )-A -[3-[(4-amino-6,7-dimethoxy-2-quina2olinyl)methylamino]propyl]tetrahydro-2-furancarboxamide monohydrochloride... 

Tin(IV) chloride Tin chloride (8) Stannane, tetrachloro- (9) (7646-78-8) Bromotris[3-(2-methoxyethoxy)propyl]stannane 2,5,13,16-Tetraoxa-9-stannaheptadecane, 9-bromo-9-[3-(2-methoxyethoxy)propyl]- (12) (130691-02-0) Dimethoxyethane Ethane, 1,2-dimethoxy- (8,9) (110-71-4)... 

The acid-catalyzed cyclization of properly substituted aminoacetaldehyde dialkyl acetals was shown to be a suitable method in the construction of a homo-isopavine (Scheme 39) (132a,172). Treatment of 7V-[l,3-bis(3,4-dimethoxy-phenyl)propyl]aminoacetaldehyde dimethyl acetal (175) with concentrated hydrochloric acid afforded the 7V-norhomoisopavine 176 in 39% yield. This cyclization was also accompanied by some O-demethylation. Product 176 could be readily N-methylated using formaldehyde and sodium borohydride to afford the homoisopavine ( )-177 (772). 

When l,l-dimethoxy-4-propyl-2,6-diphenyl-A5-phosphorin (53) is transformed into its 4-carbenium tetrafluoroborate (54) and treated with a base the 4-(l-propenyl) derivative (55) is formed. This, by a two phase oxidation with KMn04, gives the aldehyde (56) which can be further transformed, e.g. into the nitrile (57 equation 34) (75AG(E)lll). An Arbusov type dealkylation of the cation salts (49) (or 54) with LiBr gives the phosphinic ester (58 equation (35)). 

A mixture of 22 g 2,5-dimethoxypropylbenzene, 23 g POCl3 and 22 g N-methylformanilide was heated on the steam bath for 1.5 h. The hot, dark reaction mass was poured into 1 L H20, which allowed the eventual separation of 2,5-dimethoxy-4-(n)-propylbenzaldehyde as a clear yellow oil weighting 14 g. Although the homologous 4-ethyl and 4-butyl benzaldehydes were clean crystalline solids, this propyl homologue remained an oil. Gas chromatographic analysis showed it to be about 90% pure, and it was used as obtained in the nitrostyrene steps with either nitromethane (here) or nitroethane (under DOPR). 

The amphetamine homologue of proscaline, 3,5-dimethoxy-4-(n)-propoxy-amphetamine is an unexplored compound. Its synthesis could not be achieved in parallel to the description given for P. Rather, the propylation of syringaldehyde to... 

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