Dimerum acid

Dimerum acid Hydroxamic acid 2 Fusarium dimerum... 

Jalal MAF, Love SK, van der Hehn D (1986) Siderophore Mediated Iron(III) Uptake in Gliocladium virens. 1. Properties of cw-Fusarinine, trani-Fusarinine, Dimerum Acid, and their Ferric Complexes. J Inorg Biochem 28 417... 

The first synthesis of a siderophore was the preparation of ferrioxamine B over 20 years ago in order to confirm the chemical structure of this natural product67). Synthesis of the other hydroxamate containing siderophores has as a central problem preparation of the constituent to-N-hydroxy amino acid in an optically pure form. The most important such subunit in hydroxamate siderophores is Ns-hydroxy ornithine. This is a chiral building block of the diketopiperazine-containing siderophores (rhodo-torulic acid 68), dimerum acid 69), coprogen 70) and coprogen B 69>), the cyclic hexa-peptides of the ferrichrome family27), the fusarinines 71 -73) and the antibiotic ferri-chrome derivatives albomycines Sl5 S2 and e 61-62). 

Fig. 31. Time dependent iron(III) uptake mediated by siderophores and synthetic analogs of rhodotorulic add (RA) n = 6 iso N,N -dihydroxy-N.N -diisopropyloc-tanediamide n = 8 me N,N -dihydroxy-N,N -methyldecanediamide n = 6 me N,N -dihydroxy-N.N -methyloctanedi-amide Dim dimerum acid Fox B ferrioxamine B Cop coprogen Fcr ferricrocin...

Taira, J., Miyagi, C., and Aniya, y. 2002. Dimerumic acid as an antioxidant from the mold, Monascus anka The inhibition mechanisms against lipid peroxidation and hemeprotein-mediated oxidation. Biochem. Pharmacol. 63(5), 1019-1026. 

Diekmann, H. Metabolic Products of Microorganisms. 81. Occurrence and Structure of Coprogen and Dimerum Acid. Arch. Mikrobiol. 73, 65 (1970). 

Dimerumic add, isolated as the active component with a radical scavenging action from the mould Monascus anka, and traditionally used for the fermentation of foods, inhibited NADPH- and iron(II)-dependent Upid peroxidation of rat Uver microsomes at 20 and 200 (M, respectively (Taira et al. 2002). The antioxidant action of dimerumic acid is due to one electron donation of the hy-droxamic add group in the dimerumic acid molecule toward oxidants resulting if formation of ni-troxide radical. 

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