Dimedone-phenylhydrazone, reaction

Section IV, 135,5), but are unaflFected by the dimedone reagent (Section 111,70, 2). The general reactions are similar to those already given under Aliphatic Ketones (Section 111,74). Owing to their higher molecular weight, such derivatives as oximes and phenylhydrazones are frequently quite satisfactory. 

MW irradiation activated the reaction of dimedone with aniline or p-chloroaniline in formic acid to give the acridines 356, which can be derivatized as the respective Ws-oxime and Ws-phenylhydrazone. However, under the same reaction condition 2-aminopyridine gave the corresponding xanthene derivative (06ARK178). 

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