Diketones enzymic reduction, specificity

Reductions of symmetrical bicyclic diketones may also be effected selectively, as illustrated in Scheme 12. The stereospecificities of the HLADH-catalyzed transformations of the unsaturated decalin-diones (25) and (27) to the corresponding hydroxy ketones (26) and (28), and in fact all specificity aspects of this enzyme, are fully predictable using a simple to use, cubic-space model of the enzyme s... 

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