Diketones, diphenyl alkynes from

Previous chapters presented examples of Pd-catalyzed carbon-hydrogen activation as a route to indole ring formation, and several new examples are presented here. Lu and coworkers effected C-H activation of A-arylamides and subsequent coupling with alkynes to give 2,3-disubsti-mted indoles (Scheme 3, equation 1) [33]. Similar indoles were synthesized by Cabrera and colleagues from a Pd-catalyzed direct combination of anilines and a-diketones (equation 2) [34], With 2,3-hexanedione, only 2-n-Pr-3-methyhndole was obtained (95%), and 4-methoxyaniline afforded 2,3-diphenyl-5-methoxyindole in lower yield... [Pg.623]

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