Diisopropylphosphoro fluoridate

Sket, D., Dettham, W-D., Clinton, M.E., Sketelj, J., Cucek, D., Brzin, M. (1991a). Prevention of diisopropylphosphoro-fluoridate-induced myopathy hy hotulinum toxin type A blockage of quantal release of acetylcholine. Acta Neuro-pathol. 82 134 2. 

Yang, Z.P., Dettham, W-D. (1996). Diisopropylphosphoro-fluoridate-induced cholinergic hyperactivity and lipid peroxidation. Toxicol. Appl. Pharmacol. 138 48-53. 

It was found that La -catalysed methanolysis of hydroxy-p-nitrophenyl phosphate (HPNPP) (76) is a model for the RNA transestrification reaction (Scheme 16). The same authors proposed catalytic methanolysis promoted by La as a new method for controlled decomposition of paraoxon (74) (Scheme 17). They found that methanolysis of (74) promoted by La(OTf)3 (Tf=0S(0)2CF3) in a methanol medium is billion-fold accelerated. Investigation of the reaction of oximate ot-nucleophiles with diisopropylphosphoro-fluoridate (DFP) (77) and two model phosphonates (78) and (79) has been... 

In other searches, using only one of the four MeSH terms (isofluorate, DFP, diisopropylphosphofluoridate, or diisopropylphosphoro-fluoridate), 3,085 results were found for those terms. Therefore, the PubMed database uses these four terms as synon3uns and the same references are foimd in any cases. They represent most, but not all, tire publications involving DFP. It should be noted that with the abbreviation of "DFP" some nonrelated publications are referred to (i.e., "bacterial DFP-flavoproteins"). Unfortunately, there is not an established tradition of indicating the CAS number for a unique reference of the chemicals in scientific publications, and standard chemical nomenclature is not always used. The statistics of the distribution of publications over time is shown in Figure 57.1. 

Phenylmethanesulfonyl fluoride (PMSF) [329-98-6] M 174.2, m 90-91 , 92-93 . Purified by recrystn from ""CgHe, pet ether or CHCl3-pet ether. [Davies and Dick J Chem Soc 483 1932 cf Tullock and Coffman J Org Chem 23 2016 I 960.] It is a general protease inhibitor (specific for trypsin and chymotrypsin) and is a good substitute for diisopropylphosphoro floridate [Fahrney and Gould 7 Am Chem Soc 85 997 1963]. 

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