Dihydroxyphenyl ethylamine

Analogously, 2-(3,4-dihydroxyphenyl)ethylamine hydrobromide (dopamine) with 4-methoxybut-3-en-2-one (warm acetic acid) forms pyridinium salt 238 (yield 31 %) and quinolinium salt 239 (yield 40%) (64AG534 65AG224 80MI2). In aqueous solution at 20°C, only 239 is obtained (yield 13%). 

Dopamine As a medicinal agent, dopamine, 2-(3,4-dihydroxyphenyl)-ethylamine (11.3.1), is synthesized by demethylation of 2-(3,4-dimethoxyphenyl)ethylamine (19.4.3) using hydrogen bromide [49-51]. 

Neurotransmitters serve to transmit signals between neurons, which are separated by a synaptic cleft. One of the neurotransmitters is dopamine (DA), or P-(3,4-dihydroxyphenyl)ethylamine (1). Until the mid-1950s dopamine was exclusively considered to be an intermediate in the biosynthesis of the catecholamines noradrenaline and adrenaline. Significant tissue levels of dopamine were first demonstrated in peripheral organs of ruminant species.1 A short time later it was found that dopamine was also present in the brain in about equal concentrations to those of noradrenaline.2... 

Dopa is decarboxylated to 2-(3,4-dihydroxyphenyl) ethylamine (dopamine) by aromatic L-amino acid decarboxylase, a nonspecific cytosolic pyridoxal phosphate-dependent enzyme also involved in formation of other amines (e.g., 5-hydroxytryptamine). 

The familiar browning of cut friut and vegetables caused by the enzyme phenolase is another aspect of the close proximity of phenolic sysztems in daily life (ref.43). Dopamine I2-(3,4-dihydroxyphenyl)ethylamine] is the causative agent implicated in recent genetic researches examining reasons for human novelty-seeking (ref. 44). 

Epinine t -[ -MeOiylaminoethyl]-catechol, N-methyl-2-[ i-dihydroxyphenyl] ethylamine)... 

DA (2-(3,4-dihydroxyphenyl)ethylamine) is an important neurotransmitter, but its electrochemical detection by oxidation is often hindered by interferents such as UA and AA. Anodized epitaxial graphene (grown on SiC) displayed resolved peaks in DPVs of DA, AA, and UA by creating edge plane defects through anodization. The anodized epitaxial graphene was also applied to... 

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