Dihydrostreptomycin toxicity

Osterberg, A. C., J. J. Olsen, N. N. Yuda, C. E. Rauh, H. G Parr, and L. W. Will. 1957. Cochlear, vestibular, and acute toxicity studies of streptomycin and dihydrostreptomycin pantothenate salts, In Antibiotics Annual, 1956-1957, edited by H. VNfelch and F. Marti-lban ez, 564-573. New York Medical Encyclopedia. 

The antibiotic potency toward numerous organisms and the toxicity of dihydrostreptomycin differed but slightly from those of streptomycin. The former was not inactivated by carbonyl reagents... 

Side effects of streptomycin and dihydrostreptomycin treatment are mainly toxic in nature. Toxicity to the auditory vestibular organs, nephrotoxicity, hepatotoxicity, and toxicity to the bone marrow have all been observed (Rasmussen 1972 Hoigne 1975). There are also reports of peripheral neuritis and neuromuscular blockade, occurring presumably as a result of the potentiation of non-depolarizing anesthetics (Hoigne 1975). Because of its strong ototoxicity, dihydrostreptomycin is no longer in use in the Western hemisphere. 

---