Dihydropyrimidine library

Kappe CO (2003) The generation of dihydropyrimidine libraries utilizing Biginelli multi-component chemistry. QSAR Comb Sci 22 630-645... 

Building Dihydropyrimidine Libraries via Microwave-Assisted Biginelli Multicomponent Reactions... 

Scheme 44 Microwave-promoted automated synthesis of dihydropyrimidine library...

The synthesis of small arrays of organic compounds derived from multicomponent condensations was recently reported by Studer et al. (119). A 10-member amino acid amide library L7 (Fig. 8.21) was prepared using the fluorous Ugi ( Flugi ) condensation, and another 10-member dihydropyrimidine library L8 (Fig. 8.21) was prepared using the Biginelli ( Fluginelli ) condensation adapted to the fluorous phase. The key intermediates for library preparation were the silyl bromide 8.36, prepared from a fluorous iodide (120), and the acyl bromide 8.37 and the acid 8.38, prepared from an orthothiobenzoate (121), as shown in Fig 8.21. The structure of the fluorous tag was... 

C. O. Kappe, QSAR Comb. Sci. 2003, 22, 630-645. The generation of dihydropyrimidine libraries utilizing Biginelh multicomponent chemistry. 

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