Dihydromorphinone hydrochloride

Oxymorphone (Numorphan ), dihydromorphinone hydrochloride, is also about ten times as active as morphine and has a rapid onset of action that lasts for about 6 h. It is administered subcutaneously or intramuscularly in doses of 1 ml (1.5 mg) or as a rectal suppository (2 and 5 mg). 

Synonym. Dihydromorphinone Hydrochloride Proprietary Name. Dilaudid Ci7Hi9N03,HC1 = 321.8 CAS—71-68-1... 

DIHYDRO-6-METHYL-2-THIOXO-4(lH)-PYRI.MIDINONE see MPW500 DIHYDROMORPHINONE HYDROCHLORIDE see DNU300... 

Hydrogenation of morphine in warm strong acid in the presence of palladium yields dihydromorphinone. Dihydromorphinone was patented by Knoll and Company (D.R.P. 365683) in 1923 and introduced under the trade name of dilaudid (77). One gram of dihydromorphinone hydrochloride dissolves in about 3 ml. of water. 

Dihydromorphinone, Cj,Hjg03N, and derivatives. Dihydromorphinone (LIII MeO HO) is formed when morphine in solution is treated with relatively large quantities of platinum or palladium catalyst under various conditions.It melts at 262-3° and yields an oxime, m.p. > 234°. The hydrochloride is the drug known as dilaudid. On 0-methyla-tion dihydromorphinone yields dihydrocodeinone (see above), and when dissolved in ether and treated with methyllithium the corresponding tertiary alcohol, 6-methyldihydromorphine, CigHggOgN, m.p. 209-211°, Wd ° 14i7° (EtOH), is formed. This on methylation with diazomethane gives 6-methyldihydrocodeine as described above (Small and Rapoport... 

---