Dihydrofolate reductase methotrexate active site interaction

Figure 1.5 Interactions of the dihydrofolate reductase active site with the inhibitor methotrexate (left) and the substrate dihydrofolate (right).

Fig, 1. Schematic drawing showing some of the interactions between the inhibitor, methotrexate, and the active site of dihydrofolate reductase from E. coli. 

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