Dihydrodipicolinate dehydrogenase

Dihydrodipicolinate synthase 2 dihydrodipicolinate dehydrogenase 3 spontaneous reaction 4 succinylase 5 succinyldiaminopimelate aminotransferase 6 succinyldiaminopimelate de-succinylase 7 diaminopimelate epimerase 8 diaminopimelate decarboxylase... 

The overall fold of MIPS is similar to that of diaminopimelic acid dehydrogenase from Corynebacterium glutamicum and dihydrodipicolinate reductase from E. coli. Though the reactions catalyzed by these enzymes are quite different, they all use either NAD+ or NADP+ bound to a structurally similar Rossmann fold domain, and all three contain a (3 sheet domain located underneath the Rossmann fold and directly beneath the nicotinamide moiety that defines part of the active site (Norman et al., 2002 Stein and Geiger, 2002). 

A further flux control step within L-lysine synthesis is the aspartate semialdehyde branch point. The aldehyde is either used as a substrate for the homoserine dehydrogenase, or together with pyruvate as a substrate for the dihydrodipicolinate synthase (Fig. 10). Whereas the homoserine dehydrogenase is allosterically controlled in its catalytic activity by the L-threonine concentration... 

Fig. 1. Bio thetic pathways for the essential aspartate-family amino adds. The numbers represent enzymes catalyzing the reaction 1, aspartate kinase 2, homoserine dehydrogenase 3, homoserine kinase 4, threonine thase 5, threonine dehydrogenase 6, acetolactate thase 7, dihydrodipicolinate thase 8, diaminopimelate decarboiylase.

The genes of the enzymes responsible for the biosynthesis of lysine in Corynebacterium have been cloned, and their nucleotide sequences are known. These genes include aspartokinase, aspartate semialdehyde dehydrogenase, dihydrodipicolinate... 

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