Dihydrobenzophenanthridine oxidase

SCHUMACHER, H.-M., ZENK, M.H., Partial purification and characterization of dihydrobenzophenanthridine oxidase from Eschscholtzia califomica cell suspension cultures. Plant Cell Rep., 1988, 7, 43-46. 

ARAKAWA, H CLARK, W.G., PSENAK, M., COSCIA, C.J., Purification and characterization of dihydrobenzophenanthridine oxidase from Sanguinaria canadensis cell cultures. Arch. Biochem. Biophys., 1992,299, 1-7. 

Ignatov, A., Clark, W.G., Cline, S.D., Psenak, M., Krueger, R.J. and Coscia, C.J. (1996) Elicitation of dihydrobenzophenanthridine oxidase in Sanguinaria canadensis cell cultures. Phytochemistry, 43,1141-4. 

Zenk, 1990). 6-Hydroxyprotopine (82) spontaneously rearranges to dihydrosanguinarine (83) (Tanahashi and Zenk, 1988,1990). Another enzyme (dihydrobenzophenanthridine oxidase) has been isolated from elicited cell suspension cultures of Eschscholtzia californica that catalyzed the oxidation of dihydrobenzophenanthridines to the quaternary alkaloids in the presence of oxygen (Schumacher and Zenk, 1988 Tanahashi and Zenk, 1988, 1990). The pro-R hydrogen at C-13 is retained in chelidonine (80) (Simanek, 1985). 

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