Dihydro-zizyphine

Recently the total synthesis of mucronine-B (150) 147), of the 4(15)-mucronine-A-type, and zizyphine-A (27) 148), the major representative of the 5(13)-type, was achieved. Total synthesis of dihydro derivatives of cyclopeptide alkaloids was more fruitful dihydro-zizyphine-A and -B 149) of the 5(13)-type, dihydro-mauritine-A 150) of the 5(14)-amphibine-B-type and dihydro-zizyphine-G 151, 152) of the 4(14)-amphibine-F-type were synthesized. The total synthesis of the linear peptide alkaloid hexaacetyl-celenamide-A was also achieved (156) 153). 

Schmidt, U., H. Bokens, A. Lieberknecht, and H. Griesser Synthesis of Peptide Alkaloids-III. Amino Acids and Peptides-XXXII. Synthesis of Dihydro-Zizyphine A and B. Tetrahedron Lett., 22, 4949 (1981). 

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