Dihexanoyl phosphatidylcholine

We have now extended these studies to synthetic phospholipids that contain short chain fatty acyl groups and which are water soluble, such as dibutyryl and dihexanoyl phosphatidylcholine (PC). These phospholipids are monomeric below their critical micelle concentration (cmc), yet activate the enzyme. In order to carry out kinetic studies, the long chain phospholipid substrate must generally be solubilized by a detergent such as Triton X-100 which serves as an inert matrix. Further understanding of the mechanism of the activation by short-chain phospholipids requires first a quantitation of the solubilization of these compounds by detergent ... 

Fernandez, C., Adeishvili, K., and Wuthrich, K. (2001a). Transverse relaxation-optimized NMR spectroscopy with the outer membrane protein OmpX in dihexanoyl phosphatidylcholine micelles. Proc. Natl. Acad. Sd. USA 98, 2358-2363. 

Abstract Sorbitol is a natural cryoprotectant for some organisms. In order to reveal the mechanism of a protection some organisms against low temperatures, we studied the interaction between sorbitol and phosphatidylcholine (PC) which is one of major component of cell membranes. Small-angle neutronscattering contrast variation method was used to characterize dihexanoyl-PC (dC(6)PC) micelles in the presence of sorbitol (2 M). As a result, the aggregation number for the dC(6)PC micelle and the volume per a single molecule in the micelle were estimated... 

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