Digoxin Aluminium hydroxide

Figure 6.20 Adsorption of digoxin by some antacids at 37 0.1°C ( ) magnesium trisilicate, (A) aluminium hydroxide gel BP (Aludrox was used in the concentration range 2.5-10%v/v), (A) light magnesium oxide, (O) light magnesium carbonate, ( ) calcium carbonate. Initial concentration of the glycoside 0.25 mg%.

Figure 10.16 Adsorption of digoxin from Lanoxin paediatric elixir at 37 0.1 °C by , Aluminium Hydroxide Gel BP (10% v/v) A, Magnesium Trisilicate Mixture BPC (10% v/v) A, Gelusil suspension (10% v/v) , Lanoxin elixir diluted 1 10 with water.

Other studies describe reductions in digoxin absorption of 11% with aluminium hydroxide, 15% with bismuth carbonate and light magnesium carbonate, and 99.5% with magnesium trisilicate. ... 

Evidence of no interaction. A study in 4 patients chronically treated with digoxin 250 to 500 micrograms daily, found that the concurrent use of either 10 mL of aluminium hydroxide mixture BP or magnesium trisilicate mixture BP, three times daily, did not reduce the bioavailability of the digoxin and none of the patients showed any reduction in the control of their symptoms. ... 

When digoxin was given with 30 mL of an aluminium/magnesium hydroxide antacid and mexiletine, the digoxin AUC was approximately halved. As mexiletine , (p.931) does not appear to interact with digoxin the interaction was attributed to the antacid. ... 

Other bioavailability studies have not found a significant interaction between digoxin capsules and aluminium/magnesium hydroxide. ... 

In vitro studies with digitoxin suggest that it might possibly interact like digoxin, and be absorbed by various antacids, but lanatoside C probably does not interact. Bioavailability studies have not found a significant interaction between beta-acetyidigoxin and aluminium/magnesium hydroxide. ... 

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