Differential binding energy

M. D. Ballinger, I. D. Zipkin, and P. A. Bartlett, Differential binding energy a detailed evaluation of the influence of hydrogen-bonding and hydrophobic groups on the inhibition of thermolysin by phosphorus-containing inhibitors,... 

Soc., 113,297 (1991). Differential Binding Energy A Detailed Evaluation of the Influence of Hydrogen Bonding and Hydrophobic Groups on the Inhibition of Thermolysin by Phosphorus-Containing Inhibitors. 

The crystallisation solvent is also an impurity and is present at very high concentrations around the crystal. Any of the mechanisms described for other impurities may also apply to the solvent and can produce similar changes in crystal habit. Finally, the interaction between solvent and crystal surface can change the surface energetics of the crystal faces due to the differential binding energies of solute and solvent on the different surfaces [58]. 

Figure 2.14 Simulation oxygen chemical potential pocMc (top), chemical potential change with respect to a 0 K gas-phase reference Apo (middle), and chemical potential change with respect to a standard state gas-phase reference Apo (bottom) vx. coverage for various simulation temperatures. The 0 K differential binding energy is also shown for comparison.

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