Diethylmalonate acidity

Dicyanocobalamin 870 3,6-Dideoxyhexoses, formation of 747 Dielectric constant 47 Diesenhofer, Johan 84 Diethanolamine, pKa value of 99 Diethylmalonic acid, pKa value of 99 Diethylpyrocarbonate reaction with histidine 126... 

Derivation By the interaction of diethyl ester or diethylmalonic acid and urea. 

Literature proposed CZE methods for phenols and derivatives using test mixtures based on aqueous buffered systems (phosphate-borate and borate " ), volatile electrolytes (ammonium hydrogencarbonate, diethylmalonic acid/dimethylamine in isopropanol and L-cysteic acid, 3-amino-1-propanesulfonic acid, aminomethanesulfonic acid, and diethylmalonic acid ), andnon-aqueous media (ammonium acetate in ACN/acetic acid in MeOH acetate, bromide, chloride, and malonate in ACN and diprotic acids/tetrabutylammonium hydroxide and maleate in MeOH ). 

Diethylpropanedioic acid (diethylmalonic acid) (Other values on Vol.3, p.l03)... 

A very profitable engagement of Fischer was the work on derivatives of malonic and barbituric esters. In 1902 the Professor of medicine, J. von Mering, whom Fischer had met in Strassburg, and who was working in Halle/Saale, visited Fischer in Berlin. He showed him a crystalline substance he had synthesized by the reaction of phosphorous oxichloride, urea and diethylmalonic acid. It seemed to be the diethyl ester of barbituric acid and he asked Fischer to confirm the constitution of this substance. Fischer found that the structure was different. With his nephew Alfred Dilthey he found two ways to obtain it. Mering tested diethylbarbituric acid and found that it was a very active soporific substance. Fischer himself used it successfully. Other derivatives of barbituric acid also showed hypnotic properties. Fischer and Mering published their results in January 1903.2 ... 

Reagents 3-picoline, 1-methylimidazole, and 1,2-dimethylimidazole were distilled under reduced pressure and stored at 5°C under a N2 atmosphere. Imidazole, diethylmalonic acid, p-nitrophenol (X = 400 nm) were purified by recrystallization. Reagent grade... 

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