Diethyl ruthenium complex

Sinou and coworkers evaluated a range of enantiopure amino alcohols derived from tartaric acid for the ATH reduction of prochiral ketones. Various (2R,iR)-i-amino- and (alkylamino)-l,4-bis(benzyloxy)butan-2-ol were obtained from readily available (-I-)-diethyl tartrate. These enantiopure amino alcohols have been used with Ru(p-cymene)Cl2 or Ir(l) precursors as ligands in the hydrogen transfer reduction of various aryl alkyl ketones ee-values of up to 80% have been obtained using the ruthenium complex [93]. Using (2R,3R)-3-amino-l,4-bis(benzyloxy)butan-2-ol and (2R,3R)-3-(benzylamino)-l,4-bis(benzyloxy)butan-2-ol with [lr(cod)Cl]2 as precursor, the ATH of acetophenone resulted in a maximum yield of 72%, 30% ee, 3h, 25 °C in PrOH/KOH with the former, and 88% yield, 28% ee, 120 h with the latter. 

Method E To a suspension of 0.67 mM of ruthenium(IV) dioxide dihydrate in 0.8 mL of trifluoroacetic acid, 0.4 mL of trifluoroacetic anhydride, and 4 mL of CH2C12 at 0 C is added, with stirring and under argon, a solution of 0.33 mM of prestegane B in 4mL of CH2C12 and, immediately, 0.2 mL of boron trifluoride-diethyl ether complex. After 3 h. the suspended solid is removed by filtration. Evaporation and flash chromatography affords the pure crystalline product yield 84% mp 228-230°C. 

In 2005, Piers et al. prepared the 14-electron (14e) phosphonium alkyh-dene ruthenium complex 24. This catalyst displays higher activity in the RCM of diethyl diallylmalonate at 0 °C when compared to the second generation catalyst 3 (> 90% conversion after 2 h for 24 versus 25% conversion after 4 h for 3 and > 90% after 5 h for the Schrock molybdenum-based catalyst) (Eq. 27). RCM reactions of trisubstituted, six-membered ring, or seven-membered ring substrates are catalyzed at room temperature affording good... 

Protonation of 322 with tetrafluoroboric acid in diethyl ether gives the cyclohexadienyl derivative 325 in 70% yield. Treatment of 325 with lithium aluminum hydride yields the biscyclohexadienyl osmium(II) complex 326. Treatment of 322 with PMe3 at 60°C gives the hydridophenyl osmium-(II) complex 181, rather than the expected arene bistrimethylphosphine osmium(O) compound, via intramolecular C—H bond activation of the benzene ligand (192,193) (Scheme 38). Compound 181 as well as the analogous ruthenium complex (92) have also been obtained directly by cocondensation of osmium or ruthenium atoms with benzene and tri-methylphosphine (62) [Eq. (44)]. 

The ambiphilic character of JT-allylmthenium complexes is in remarkable contrast to palladium chemistry [29]. A series of (jt-C3H5)RuX(CO)3 (X = Br, OAc or OTf) complexes prefer the attack of electrophiles such as aldehydes as well as the attack of nucleophiles such as NaCH(C02Me)2, while Jt-allylpalladium complexes react exclusively with nucleophiles. Thus, stoichiometric reactions of Jt-allylmthenium complex with benzaldehyde and the sodium salt of diethyl malonate afford the corresponding homoallyl alcohol and allylmalonate, respectively (Scheme 5.1). The carbonyl ligand plays a very important role, and ambiphilic reactivity is realized only in ruthenium complexes bearing a carbon monoxide ligand. 

Dicobalt iron and dicobalt ruthenium cluster complexes, 26 351 Diethyl ether, ytterbium complex, 27 148 ruthenium complex, 27 198 Diphosphene, bis(2,4,6-tri-lerf-butyl-phenyl)-, 27 241... 

OHj, Water, chromium and vanadium complexes, 27 307, 309 iridium complex, 26 123, 28 58 ruthenium complex, 26 254-256 OlPjRhCjjHgg, Rhodium(I), carbonyliodo-bis(tricyclohexylphosphine)-, 27 292 OLiNC,jH22, Lithium, (diethyl ether)(8-(dimethylamino)-l-naphthyll-, 26 154 OLUC21H25, Lutetium, bis(ii -Cyclopenta-dienyl)(tetrahydrofuran)-p-tolyl-,... 

The phosphine-containing ruthenium dihydride dendrimer 33 was found to be an active catalyst for the diastereoselective Michael addition of ethyl cyanoacetate to diethyl ethylidenemalonate in THF (Scheme 12). The dendritic catalyst showed an activity and selectivity similar to those of the reference compound RuH2(PPh3)4 (100% conversion after 24 h and a diastereoselectivity of 7/3) (40). The dendritic catalyst was recycled twice by precipitation with diethyl ether without loss of activity or selectivity. Complex 34 showed similar activity and recoverability over three runs like that of complex 33. 

The product of stannous chloride and the carbonylated ruthenium chloride solution gives a cationic complex with diethyl sulfide (169). 

Ru(methallyl)2(cyclooctadiene) is prepared by addition of polymeric dichloro(cy-clooctadiene)ruthenium to a suspension of (2-methylpropenyl)magnesium chloride in diethyl ether, and stirring at room temperature for 1.5 h. After hydrolysis with cold water at -40 °C, the reaction mixture is extracted twice with diethyl ether. Evaporation of the solvent furnishes a gray powder in 80 % yield. This complex (2.0 g, 6.26 mmol) and 2.6 g (6.10 mmol) l,3-bis(diphenylphosphino)butane are... 

---