Diet pills phentermine

Figure 4.1 The chemical structure of amphetamine and fenfluramine are illustrated here. Fenfluramine (bottom) is a diet pill that is very similar in structure to amphetamine (top). Fenfluramine is an appetite suppressant, like amphetamine, but it does not have stimulant effects. Fenfluramine was proposed as a safer alternative to amphetamine and was very effective in causing weight loss, especially when used in combination with phentermine. Unfortunately, fenfluramine eventually led to devastating side effects, which led to its being withdrawn from the U.S. market.

Additional ADRs linked to diet pills include psychosis myocardial ischemia drug interactions, such as the interaction of fenfluramine with imipramine, fenfluramine with amitriptyline or desipramine, or the toxic reaction between fluoxetine and phentermine and the release of serotonin while inhibiting its reuptake, contributing to hyperserotonin reactions. When the next craze takes hold of patients and their physicians, hopefully physicians and pharmacists will take a more vocal position and recommend restraint, xmtil some proof of efficacy and lack of toxicity is shown for new faddish off-label combinations. 

The diet pills developed to replace amphetamines became known as anorectics or appetite suppressants and are central nervous system stimulants. The FDA approved phentermine in 1959, fenfluramine in 1973, and dexfenfluramine in 1996. 

Amphetamine stimulates the central nervous system, which suppresses the appetite. Most diet pills are sympathomimetics. They are similar to amphetamines, but are less powerful and have less potential for addiction. The sympathomimetics are benzphetamine, diethylpropion, mazindol, methamphetamine, phendimetrazine, phentermine, and sibutramine. 

Pethidine see Meperidine Peyote see Mescaline Phendimetrazine see Diet pills Phenelzine see Antidepressants Phenobarbital see Barbiturates Phentermine see Diet pills... 

---