Temperature and dielectric constants

The intrinsic pKas of the proteins depend on the local environment. They are further influenced by ionic strength, dielectric constant, and temperature. Mobility estimates should account for the effective mass-to-charge ratio and molecular shape contributions. The denaturation processes produce sets of... 

In 1926, Bjerrum [137] used Debye-Hiickel theory to describe ion association and took into account the interaction of ions within a short range. He introduced an ion-pair concept, gave a definition of ion pairs as neutral species formed by electrostatic attraction between oppositely charged ions in solution, and showed how ion-pair formation was dependent on the ions size (radius of ions), solvent (dielectric constant), and temperature. 

The exact value varies, of course, according to the Boltzmann distribution between the conformations, which in turn is dependent upon solvent, dielectric constant, and temperature. This could all be taken into account if desired, but the overall changes would be small. 

Spectrophotometric study of the kinetics of addition of Ph3P to R02CC=CC02R and/or pyrrole revealed that the rate constant (A 2) decreases with decreasing solvent dielectric constant and temperature the overall reaction has been found to be of first order in both components. The activation parameters AG, A5, and A// for the initial rate-determining step as an elementary reaction have been determined. The ( )-isomer of the product proved to be the more stable, both experimentally and theoretically. ... 

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