Dideoxy synthesis

DL-Alk-2-enopyranos-4-uIose, 2,3-dideoxy-synthesis, 1, 426 Alkoxy nitroxide radicals pyridines ESR, 2, 146 Alkyl cyanides trimerization, 3, 503 Alkylating agents as pharmaceuticals, 1, 157 Alkylation... 

Hexamine — see Hexamethylenetetramine 1,4,7,10,13,16-Hexaoxacyclooctadecane — see [18]Crown-6 Hexazinone as herbicide, 1, 187 Hex-2-enopyranoside, 2,3-dideoxy-synthesis, 1, 464 Hexobarbital, 3, 150 Hexogen, 3, 530 a-D-galacto- Hexopyranose nomenclature, 1, 31 Qf-D-ido-Hexopyranose nomenclature, 1, 31... 

Fig. 6. DNA sequence analysis, (a) Simplified methodology for dideoxy sequencing. A primer, 5 -TCTA, hybridized to the template, is used to initiate synthesis by DNA polymerase, (b) Stmcture of 2, 3 -dideoxy CTP. When no 3 -OH functionaUty is available to support addition of another nucleotide to the growing chain, synthesis terminates once this residue is incorporated into the synthetic reaction, (c) Representation of a DNA sequencing gel and the sequence, read from bottom to the top of the gel, gives sequence information in the conventional 5 to 3 direction.

A presentation by Webber and co-workers dealing with the synthesis of fluorodeoxy sugars regrettably had to be left out of this monograph because of unexpected difficulties in the preparation of the manuscript. The fourth aspect was represented in the symposium by two presentations involving important aspects of deoxy and dideoxy sugars by Osborn and Heath respectively which unfortunately were not incorporated in this monograph. 

An attractive feature in this reaction is the possibility of direct substitution and formation of unblocked sugar derivatives containing one or more chlorodeoxy function in essentially two steps. Another facet is the formation of methyl 4,6-dichloro-4,6-dideoxy-hexosides from certain methyl glycosides in one step. Such compounds could be valuable intermediates in the synthesis of dideoxy and diamino sugars of biological importance. 

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