Didemnum molle cyclodidemnamide from

Another tunicate, Didemnum molle, has been shown to contain a novel series of cyclic peptides. They include the hexapeptides comoramides A (391) and B (392) [301] and the heptapeptides, mollamide (393) [302], cyclodidemnamide (394) [303], and mayotamides A (395) and B (396) [301]. The structures of these compounds were elucidated from spectral data, degradation experiments and, in the case of mollamide (393), by X-ray analysis. The total synthesis of cyclodidemnamide led to the revision of its structure [304]. All of them exhibited cytotoxic activity and 393 also inhibited RNA synthesis [302]. 

Boden, C.D.J., Norley, M and Pattenden, G. (2000) Total synthesis and assignment of configuration of the thiazoline-based cyclopeptide cyclodidemnamide isolated from the sea squirt Didemnum molle. J. Chem. Soc. Perkin Trans. 1, 883-888. 

Toske, S.G. and Fenical, W. (1995) Cyclodidemnamide a new cyclic heptapeptide from the marine ascidian Didemnum molle. Tetrahedron Lett., 36, 8355-8358. 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ , ]

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