Magnesium hydroxide Dicoumarol

Dicoumarol + magnesium hydroxide, magnesium oxide Opposite effects have been reported (i) Decreased absorption and lower blood levels (up to 75%) of dicoumarol (ii) Increased absorption Possibly adsorption on drug leading to decreased absorption. Chelation might lead to more lipophilic species and increased absorption Space doses by 2-3 h... 

Rgure 10.10 Plasma levels of bishydroxycoumarin (BHC), also known as dicoumarol, in 6 subjects after a 300 mg oral dose with water (solid line), magnesium hydroxide (dotted line) or aluminium hydroxide (dashed line). Closed data points represent a significant difference from control. 

There is some evidence that the absorption of dicoumarol may be increased by magnesium hydroxide, but there is no direct evidence that this is clinically important. Aluminium hydroxide does not interact with either warfarin or dicoumarol, and magnesium hydroxide does not interact with warfarin. 

Magnesium hydroxide (Milk o/Magnesia) 15 mL taken with and 3 hours after a single dose of dicoumarol was found to raise the peak plasma levels and AUC of dicoumarol by 75% and 50%, respectively, in 6 healthy subjects. Conversely, aluminium hydroxide (Amphogel) 30 mL did not alter dicoumarol levels. ... 

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