Diclofenac transformation product

Vogna et al. (2004) showed that UV/H2O2 (as well as molecular ozone) was effective at oxidizing transformation products of the pharmaceutical, diclofenac. Lau et al. (2007) studied the formation of a suite of ten transformation products of butylated hydroxyanisole by including 1,4-benzoquinone, f-butyl-l,4-benzoquinone, and hydroquinone. Some of the degradates were precipitated from solutions as an orange-colored solid that could be removed by filtration. The study showed that UV/ozone and ozonation were more effective than UV alone at removal of the parent and transformation products. 

Fig. 9.16. (a) Mass spectrum of unknown transformation product of diclofenac, reisolated in a second EDAstudy. (b) Mass spectrum of the synthesized standard, CPAB. Source [283]. 

G. Streck, and W. Brack. Identification of a photo-transformation product of diclofenac using effect-directed analysis. Environ. Pollut, 158(5) 1461-1466, 2010. 

A series of halogenated transformation products of pharmaceuticals and related environmental contaminants have been characterized by Larive et by the use of H and NMR including /hh couplings this included chloro- and bromoderivatives of salicylic acid and halogenated analogues of naproxen, gemfibrozil, diclofenac, tertiary octyl-phenol and bisphenol A. 

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