Diclofenac migraine

If the oral route is unsuccessful, a rational alternative is to use suppositories of diclofenac 100 mg for pain and domperidone 30 mg for vomiting, although the diarrhoea that may accompany migraine would compromise their efficacy. Efficient use of an analgesic and an antiemetic is adequate for the majority of acute attacks. 

Analgesic/ Anti-inflammatory Non-prescription treatment of colds, allergies, pain Prescription treatment of chronic pain, arthritis, migraines, etc. ASA (aspirin), ibuprofen, indomethacin, acetaminophen Naproxen, diclofenac, propyphenazone, codeine 33, 40, 55, 61, 62... 

Caffeine modestly increases the bioavailability, rate of absorption and plasma levels of aspirin. Adding caffeine to diclofenac may improve its efficacy in the treatment of migraine. 

Peroutka SJ, Lyon JA, Swarbrick J, Lipton RB, Kolodner K, Goldstein J. Efficacy of diclofenac sodium sof el 100 mg with or without caffeine 100 mg in migraine without aura a randomized, double-blind, crossover sbufy. Headache (2004) 44,136-41. 

Microemulsion provided differential release of zolmitriptan Mid diclofenac acid both in vitro and in vivo that may be potentially beneficial to migraine patients. 

Dubey R, Martini LG, and Christie M. (2013). Duel-acting subcutaneous microemulsion formulation for improved migraine treatment with Zolmitriptan and Diclofenac Formulation and in vitro-in vivo characterization. AAPSJ, 16, 214-220. 

As an NSAID, diclofenac is easy to use, and has been shown to be efficacious in arthritic syndromes, as well as for acute treatment of migraines, and small procedures. A major advantage of diclofenac, as with other NSAIDs, is its use in multimodal analgesia. In patients who are post-operative or with certain chronic pain syndromes, diclofenac can be used to provide additive analgesia and an opioid-sparing effect. Diclofenac has decreased side effects when compared to opioids in terms of nausea, respiratory depression, sedation, and constipation. 

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