Magnesium hydroxide Diclofenac

The absorption of diclofenac is not affected by aluminium hydroxide, magnesium hydroxide, or the combination. 

About 10 mL of a 5.8% suspension of aluminium hydroxide had no effect on the bioavailability of a single 50-mg dose of diclofenac i n 7 healthy subjeets. In another study, 10 mL of magnesium hydroxide suspension (850 mg) was found to have no signifieant effect on the rate or extent of absorption of a single 50-mg dose of dielofenac in 6 healthy, fasted sub-jeets. However, there was a tendeney to an increased rate of absorption. Aluco Gel (aluminium/magnesium hydroxide) had no effect on the extent of absorption of enterie-eoated dielofenac, but may have reduced the rate of absorption. No partieular preeautions would seem to be needed if these antaeids are given with dielofenae. 

Neuvonen PJ. The effect of magnesium hydroxide on the oral absorption of ibuprofen, keto-profen and diclofenac. BrJ Clin Pharmacol ( 99 ) 31,263-6. 

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See also in sourсe #XX -- [ ]

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